Maternal exposure to endocrine disrupting chemicals (EDCs) and preterm birth: A systematic review, meta-analysis, and meta-regression analysis.
Maternal exposure to endocrine disrupting chemicals (EDCs) and preterm birth: A systematic review, meta-analysis, and meta-regression analysis.
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DOI：
10.1016/j.envpol.2021.118264
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发表时间：
2021-10
影响因子：
8.9
通讯作者：
Yuhao Wu;Jun-ke Wang;Yuexin Wei;Jiadong Chen;Lian Kang;Chun-lan Long;Shengde Wu;Lianju Shen;G. Wei
中科院分区：
文献类型：
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作者：
Yuhao Wu;Jun-ke Wang;Yuexin Wei;Jiadong Chen;Lian Kang;Chun-lan Long;Shengde Wu;Lianju Shen;G. Wei
早产是5岁以下儿童死亡的第二大常见原因。早产的病因尚未阐明。虽然母体暴露于内分泌干扰物（EDCs）可能会增加早产的风险，但尚未证实相关性。我们进行了一项荟萃分析，以阐明母亲暴露于内分泌干扰物和早产之间的关系。2021年7月，对PubMed、Ovid-EMBASE和科克伦图书馆（CENTRAL）进行了一次系统性检索，以获得相关的已发表研究，这些研究提供了母体EDC暴露与人类早产之间相关性的定量数据。为了计算总体估计值，我们通过逆方差法合并了每项研究的校正回归系数和95%置信区间（CI）。共纳入59项研究。汇总结果表明，母体暴露于金属（OR，1.23; 95% CI，1.17至1.29）和邻苯二甲酸酯（OR，1.31; 95% CI，1.21至1.42）与早产风险增加相关。具体而言，母亲接触铅、镉、铬、铜和锰似乎与早产风险升高相关。此外，母体暴露于邻苯二甲酸单乙酯（MEP）、邻苯二甲酸单-2-乙基-5-羧基戊酯（MECPP）、邻苯二甲酸单苄酯（MBzP）和邻苯二甲酸二（2-乙基己基）酯（DEHP）也与早产相关。总之，根据目前的证据，母亲暴露于金属和邻苯二甲酸盐可能会增加早产的风险。
Preterm birth is the second most common cause of death in children under 5 years of age. The etiology of preterm birth has not yet been elucidated. Although maternal exposure to endocrine disrupting chemicals (EDCs) may increase the risk for preterm birth, associations have not been confirmed. We performed a meta-analysis to elucidate the relationships between maternal exposure to EDCs and preterm birth. A systematic search of PubMed, Ovid-EMBASE, and the Cochrane Library (CENTRAL) for relevant published studies providing quantitative data on the association between maternal EDC exposure and preterm birth in humans was conducted in July 2021. To calculate the overall estimates, we pooled the adjusted regression coefficients with 95% confidence intervals (CIs) from each study by the inverse variance method. A total of 59 studies were included. The pooled results indicated that maternal exposure to metals (OR, 1.23; 95% CI, 1.17 to 1.29) and phthalates (OR, 1.31; 95% CI, 1.21 to 1.42) was related to an increased risk for preterm birth. Specifically, maternal exposure to lead, cadmium, chromium, copper and manganese appeared to be correlated with an elevated risk for preterm birth. Additionally, maternal exposure to monoethyl phthalate (MEP), mono-2-ethyl-5-carboxypentyl phthalate (MECPP), monobenzyl phthalate (MBzP), and di (2-ethylhexyl) phthalate (DEHP) was also associated with preterm birth. In conclusion, maternal exposure to metals and phthalates may increase the risk for preterm birth based on current evidence.