Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients
Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients
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DOI：
10.1016/j.lfs.2003.10.022
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发表时间：
2004-04-16
期刊：
影响因子：
6.1
通讯作者：
Kamataki, T
中科院分区：
文献类型：
--
作者：
Yamazaki, H;Fujieda, M;Kamataki, T
三甲胺尿 (TMAU) 是一种代谢紊乱，其特征是无法将膳食来源的三甲胺 (TMA) 氧化和转化为三甲胺 N-氧化物 (TMAO)。这种疾病在欧洲和北美人群中已有相对充分的记录，但尚未出现有关日本患者的报道。我们发现了 7 名日本人，他们将 TMA 转化为其无味代谢物 TMAO 的代谢能力较低。这七个人的代谢能力（以尿液中排出的 TMAO 浓度除以 TMA 浓度加上 TMAO 浓度来定义）范围为 70% 至 90%。相比之下，健康对照者将 TMA 转化为 TMAO 的代谢能力均低于 95%。膳食木炭的摄入（每天总共 1.5 克木炭，持续 10 天）降低了尿中游离 TMA 浓度，并将 TMAO 浓度增加到木炭施用期间的正常值。叶绿素铜（每天总计 180 毫克，持续 3 周）也能有效降低尿中游离 TMA 浓度，并将 TMAO 增加至正常个体的浓度。在接受检查的 TMAU 受试者中，叶绿酸铜的作用似乎比活性炭的作用持续时间更长（即几周）。结果表明，每日摄入木炭和/或叶绿酸铜可能对改善 TMAU 患者的生活质量具有重要作用。 (C) 2004 Elsevier Inc. 保留所有权利。
Trimethylaminuria (TMAU) is a metabolic disorder characterized by the inability to oxidize and convert dietary-derived trimethylamine (TMA) to trimethylamine N-oxide (TMAO). This disorder has been relatively well-documented in European and North American populations, but no reports have appeared regarding patients in Japan. We identified seven Japanese individuals that showed a low metabolic capacity to convert TMA to its odorless metabolite, TMAO. The metabolic capacity, as defined by the concentration of TMAO excreted in the urine divided by TMA concentration plus TMAO concentration, in these seven individuals ranged from 70 to 90%. In contrast, there were no healthy controls examined with less than 95% of the metabolic capacity to convert TMA to TMAO. The intake of dietary charcoal (total 1.5 g charcoal per day for 10 days) reduced the urinary free TMA concentration and increased the concentration of TMAO to normal values during charcoal administration. Copper chlorophyllin (total 180 mg per day for 3 weeks) was also effective at reducing free urinary TMA concentration and increasing TMAO to those of concentrations present in normal individuals. In the TMAU subjects examined, the effects of copper chlorophyllin appeared to last longer (i.e., several weeks) than those observed for activated charcoal. The results suggest that the daily intake of charcoal and/or copper chlorophyllin may be of significant use in improving the quality of life of individuals suffering from TMAU. (C) 2004 Elsevier Inc. All rights reserved.