The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.
The African Turquoise Killifish Genome Provides Insights into Evolution and Genetic Architecture of Lifespan.
复制标题
非洲绿松石杀死基因组提供了对生命周期进化和遗传结构的见解。
DOI：
10.1016/j.cell.2015.11.008
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发表时间：
2015-12-03
期刊：
影响因子：
64.5
通讯作者：
Brunet A
中科院分区：
文献类型：
--
作者：
Valenzano DR;Benayoun BA;Singh PP;Zhang E;Etter PD;Hu CK;Clément-Ziza M;Willemsen D;Cui R;Harel I;Machado BE;Yee MC;Sharp SC;Bustamante CD;Beyer A;Johnson EA;Brunet A
在自然界中，寿命是一个非常多样化的特征，从几天到几百年不等，但寿命差异进化的机制仍然难以捉摸。在这里，我们从头组装一个参考基因组的自然短命的非洲绿松石鳉，比较和实验基因组学提供了一个独特的资源。在这种鱼的正选择下的基因识别揭示了解释其压缩寿命的潜在候选人。在这种短命鱼和长寿物种中，几个衰老基因处于正选择状态，这提出了一种有趣的可能性，即同一基因可能是缩短和延长寿命的进化基础。比较基因组学和连锁分析确定候选基因与不同的绿松石鳉鱼品系之间的寿命差异。值得注意的是，这些基因聚集在性染色体上，这表明短寿命可能与性别决定共同进化。我们的研究提供了对自然界中塑造寿命的进化力量的见解。
Lifespan is a remarkably diverse trait ranging from a few days to several hundred years in nature, but the mechanisms underlying the evolution of lifespan differences remain elusive. Here we de novo assemble a reference genome for the naturally short-lived African turquoise killifish, providing a unique resource for comparative and experimental genomics. The identification of genes under positive selection in this fish reveals potential candidates to explain its compressed lifespan. Several aging genes are under positive selection in this short-lived fish and long-lived species, raising the intriguing possibility that the same gene could underlie evolution of both compressed and extended lifespans. Comparative genomics and linkage analysis identify candidate genes associated with lifespan differences between various turquoise killifish strains. Remarkably, these genes are clustered on the sex chromosome, suggesting that short lifespan might have co-evolved with sex determination. Our study provides insights into the evolutionary forces that shape lifespan in nature.