Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping
Ephrin-As and neural activity are required for eye-specific patterning during retinogeniculate mapping
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DOI：
10.1038/nn1508
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发表时间：
2005-08-01
影响因子：
25
通讯作者：
Feldheim, DA
中科院分区：
文献类型：
--
作者：
Pfeiffenberger, C;Cutforth, T;Feldheim, DA
在哺乳动物中，视网膜神经节细胞（RGC）投射最初混合，然后分离成背外侧膝状体核（dLGN）中眼睛特异性层的刻板模式。在这里，我们发现，在缺乏ephrin-A2，ephrin-A3和ephrin-A5的小鼠中，眼睛特异性输入分离，但眼睛特异性层的形状和位置被严重破坏。相比之下，缺乏相关视网膜活动的小鼠没有分离眼睛特异性输入。肝配蛋白突变体中相关神经活动的抑制导致位于dLGN不适当区域的重叠视网膜投射。因此，肝配蛋白-As和神经活性一起作用以控制眼睛特异性视网膜小神经层的图案化。
In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted. In contrast, mice that lacked correlated retinal activity did not segregate eye-specific inputs. Inhibition of correlated neural activity in ephrin mutants led to overlapping retinal projections that were located in inappropriate regions of the dLGN. Thus, ephrin-As and neural activity act together to control patterning of eye-specific retinogeniculate layers.