Increased plasma free tryptophan levels in human cancer: a tumor related effect?
Increased plasma free tryptophan levels in human cancer: a tumor related effect?
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发表时间：
1991-05
影响因子：
2
通讯作者：
A. Cascino;C. Cangiano;F. Ceci;F. Franchi;T. Mineo;M. Mulieri;M. Muscaritoli;F. Rossi Fanelli
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文献类型：
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作者：
A. Cascino;C. Cangiano;F. Ceci;F. Franchi;T. Mineo;M. Mulieri;M. Muscaritoli;F. Rossi Fanelli
在癌症患者（CP）中发现高游离色氨酸（F-TRP）血浆水平。F-TRP血浆浓度受其载体白蛋白（ALB）和与TRP竞争ALB结合位点的游离脂肪酸（FFA）水平的影响。CP中F-TRP、ALB和FFA之间缺乏相关性表明F-TRP升高具有肿瘤依赖性效应。为了验证这一假设，F-TRP，ALB和FFA水平测定在12个肺和16个乳腺CP容易根治性手术，手术切除肿瘤前和15天后。肿瘤消融后F-TRP水平显著降低。由于F-TRP、ALB和FFA之间没有相关性，因此可以认为肿瘤本身可能是导致CP中F-TRP水平升高的原因。
High free tryptophan (F-TRP) plasma levels are found in cancer patients (CP). F-TRP plasma concentrations are affected by the levels of its carrier, albumin (ALB), and free fatty acids (FFA) competing with TRP for ALB binding sites. The lack of correlation between F-TRP, ALB and FFA in CP suggests a tumor-dependent effect on the rise in F-TRP. To verify this hypothesis, F-TRP, ALB and FFA levels were assayed in 12 lung and 16 breast CP susceptible to radical surgery, before and 15 days after surgical removal of the tumor. F-TRP levels significantly decreased after tumor ablation. Since no correlation was found between F-TRP, ALB and FFA variations, it is conceivable that the tumor itself may be responsible for the high F-TRP levels in CP.