Serum hyaluronate correlates with histological progression in alcoholic liver disease
Serum hyaluronate correlates with histological progression in alcoholic liver disease
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DOI：
10.1097/00042737-200309000-00002
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发表时间：
2003-09-01
影响因子：
2.1
通讯作者：
Seitz, HK
中科院分区：
文献类型：
--
作者：
Stickel, F;Poeschl, G;Seitz, HK
目的长期饮酒可导致肝硬化的发生。血清透明质酸浓度被认为是慢性肝病的预测因子，但其区分纤维化和炎症严重程度的能力尚未得到评估。为了评价透明质酸作为检测酒精性肝病早期阶段的标志物并建立与肝组织学的可能相关性，通过放射免疫测定法测量了87例活检证实的脂肪肝、脂肪肝和轻度纤维化、脂肪肝和炎症、严重纤维化和炎症以及肝硬化患者和12例非酒精性对照受试者的血清浓度。此外，血清透明质酸测定在40个非酒精性酒精患者与正常的血清天门冬氨酸氨基转移酶（AST）或AST升高至少两个folds.Results血清透明质酸增加显着与酒精性肝病的晚期，而脂肪肝患者的水平仅略有升高，没有达到显着。羟乙磺酸与组织学分期相关性良好，对检测一般纤维化和小静脉周围纤维化作为进展为肝硬化的指标高度敏感。结论血清透明质酸水平是一个很好的预测存在中度肝纤维化的酒精性肝病，证明其临床应用，以评估酗酒者的肝脏形态学改变。(C)2003年利平科特威廉姆斯威尔金斯。
Objectives Chronic alcohol consumption may lead to the development of liver cirrhosis. Serum concentrations of hyaluronate were suggested as a predictor in chronic liver disease, but its power to distinguish between severity of fibrosis and inflammation had not been assessed. In order to evaluate hyaluronate as a marker to detect early stages of alcoholic liver disease and to establish a possible correlation with hepatic histology, serum concentrations were measured by radioimmunoassay in 87 patients with biopsy-proven fatty liver, fatty liver and mild fibrosis, fatty liver and inflammation, severe fibrosis and inflammation, and cirrhosis, and in 12 non-alcoholic control subjects. In addition, serum hyaluronate was determined in 40 non-cirrhotic alcoholic patients with either a normal serum aspartate aminotransferase (AST) or an AST elevated at least two-fold.Results Serum hyaluronate increased significantly with advanced stages of alcoholic liver disease, while levels in patients with fatty liver were elevated only slightly without reaching significance. Hyaluronate correlated well with histological stage and was highly sensitive for detecting fibrosis in general and perivenular fibrosis as an indicator of progression to cirrhosis. Hyaluronate levels were not influenced by AST levels.Conclusion Serum hyaluronate is a good predictor of the presence of even moderate hepatic fibrosis in alcoholic liver disease, justifying its clinical use to assess morphological alterations of the liver in alcoholics. (C) 2003 Lippincott Williams Wilkins.