Amino acid capture and utilization within the Mycobacterium tuberculosis phagosome
Amino acid capture and utilization within the Mycobacterium tuberculosis phagosome
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DOI：
10.2217/fmb.14.28
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发表时间：
2014-05-01
影响因子：
3.1
通讯作者：
Neyrolles, Olivier
中科院分区：
文献类型：
--
作者：
Gouzy, Alexandre;Poquet, Yannick;Neyrolles, Olivier
结核分枝杆菌是结核的病原体，是一种兼性细胞内细菌病原体，在宿主巨噬细胞和其他吞噬细胞内的膜结合液泡或吞噬体内复制。结核分枝杆菌如何捕获和利用宿主细胞内的重要营养物质是一个密集的研究领域，可能会导致结核病的新疗法。最近的报告提供了证据，证明结核分枝杆菌依靠氨基酸摄取和降解途径在其宿主内茁壮成长。这为开发创新的抗结核药物开辟了新的研究场所。
Mycobacterium tuberculosis, the agent of TB, is a facultative intracellular bacterial pathogen that replicates inside host macrophages and other phagocytes within a membrane-bound vacuole or phagosome. How M. tuberculosis captures and exploits vital nutrients inside host cells is an intensive research area that might lead to novel therapeutics for tuberculosis. Recent reports provided evidence that M. tuberculosis relies on amino acid uptake and degradation pathways to thrive inside its host. This opens novel research venues for the development of innovative antimicrobials against TB.