The Behavioral Phenotype of 7q11.23 Duplication Syndrome Includes Risk for Oppositional Behavior and Aggression.
The Behavioral Phenotype of 7q11.23 Duplication Syndrome Includes Risk for Oppositional Behavior and Aggression.
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DOI：
10.1097/dbp.0000000000001068
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发表时间：
2022-08-01
影响因子：
2.4
通讯作者：
Mervis, Carolyn B.
中科院分区：
文献类型：
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作者：
Klein-Tasman, Bonita P.;Yund, Brianna D.;Mervis, Carolyn B.
7q11.23重复综合征(Dup7)是一种与认知和行为特征相关的表型可变的遗传性疾病，包括表达语言困难、社交焦虑和对立或破坏性行为的高发。对攻击性和对抗性的相关性进行了研究。参与者是63名4至17岁之间患有遗传确诊Dup7的儿童。采用多方法、多信息者方法评估攻击性和对立行为，并考虑了认知功能、表达语言、自闭症、社交焦虑和多动/冲动症状的贡献。更高水平的攻击性和对立行为被发现。认知功能、表达语言和自闭症症状与父母的攻击性评分没有显著关系，尽管有语言和非语言认知障碍的幼儿最有可能表现出考官观察到的攻击性。社交焦虑和多动/冲动症状与违抗/攻击和反对行为有关。在Dup7中复制的7q11.23区域的基因，在与环境的交易中，可能有助于攻击和反对行为。
7q11.23 duplication syndrome (Dup7) is a genetic disorder with a variable phenotype associated with cognitive and behavioral characteristics including a high incidence of expressive language difficulties, social anxiety, and oppositional or disruptive behavior. Correlates of aggression and oppositionality were examined. Participants were 63 children with genetically confirmed Dup7 between the ages of 4 and 17 years. A multi-method, multi-informant approach was used to assess aggression and oppositional behavior, and the contributions of cognitive functioning, expressive language, and autism spectrum, social anxiety, and hyperactivity/impulsivity symptomatology were considered. Elevated levels of aggression and oppositional behavior were found. Cognitive functioning, expressive language, and ASD symptomatology were not significantly related to parent ratings of aggression, although young children who had language and nonverbal cognitive delays were most likely to demonstrate examiner-observed aggression. Social anxiety and hyperactivity/impulsivity symptomatology were related to defiant/aggressive and oppositional behavior. Genes in the 7q11.23 region duplicated in Dup7, in transaction with the environment, may contribute to aggressive and oppositional behavior.