Evolutionary diversification of the multimeric states of proteins
Evolutionary diversification of the multimeric states of proteins
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DOI：
10.1073/pnas.1310980110
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发表时间：
2013-07-23
影响因子：
11.1
通讯作者：
Lynch, Michael
中科院分区：
文献类型：
--
作者：
Lynch, Michael
蛋白质最显著的特征之一是它们通常组装成多聚体结构，通常是具有偶数个亚基的同聚体，这些亚基都来自同一遗传位点。然而，虽然大量的结构变异的orthophosphate蛋白存在内部和之间的主要系统发育谱系，在形成鲜明对比的基因结构和基因组组织的模式，似乎没有蛋白质结构的复杂性和生物体的复杂性之间的相关性。此外，没有证据表明蛋白质结构差异是由选择压力的谱系特异性差异驱动的。在这里，它表明，蛋白质的多聚体状态的变化可以很容易地产生从突变和随机遗传漂变的联合过程中产生的随机转换，即使在面对一个特定的蛋白质结构在所有谱系的恒定定向选择。在所提出的假设下，在一个长的进化时间尺度上，从单体到二聚体的转变的数量应该近似于相反方向的数量，并且对于高阶结构之间的转变也是如此。
One of the most striking features of proteins is their common assembly into multimeric structures, usually homomers with even numbers of subunits all derived from the same genetic locus. However, although substantial structural variation for orthologous proteins exists within and among major phylogenetic lineages, in striking contrast to patterns of gene structure and genome organization, there appears to be no correlation between the level of protein structural complexity and organismal complexity. In addition, there is no evidence that protein architectural differences are driven by lineage-specific differences in selective pressures. Here, it is suggested that variation in the multimeric states of proteins can readily arise from stochastic transitions resulting from the joint processes of mutation and random genetic drift, even in the face of constant directional selection for one particular protein architecture across all lineages. Under the proposed hypothesis, on a long evolutionary timescale, the numbers of transitions from monomers to dimers should approximate the numbers in the opposite direction and similarly for transitions between higher-order structures.