Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys.
Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeys.
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DOI：
10.1038/nn.2197
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发表时间：
2008-10
影响因子：
25
通讯作者：
Lisberger, Stephen G.
中科院分区：
文献类型：
--
作者：
Medina, Javier F.;Lisberger, Stephen G.
小脑学习假说认为，浦肯野细胞中复杂的棘波参与了小脑皮质的可塑性机制；反过来，小脑的变化抑制了浦肯野细胞对给定刺激的简单棘波反应，并导致运动行为的适应性改变。尽管这一假说的许多要素已经得到了先前的实验的支持，但在学习过程中，复杂的尖峰电位、简单的尖峰电位可塑性和行为之间的联系还没有同时被检验。我们现在率先对清醒行为的猴子的浦肯野细胞反应进行了一次又一次的分析，结果强烈支持复杂的棘波在简单的运动学习任务中诱导小脑可塑性的因果作用。我们表明，在一个学习试验中出现复杂的尖峰电位与随后的试验中简单尖峰反应的显著抑制有关，而在行为学习表现出来的时候。
The hypothesis of cerebellar learning proposes that complex spikes in Purkinje cells engage mechanisms of plasticity in the cerebellar cortex; in turn, changes in the cerebellum depress the simple spike response of Purkinje cells to a given stimulus and cause the adaptive modification of a motor behavior. Although many elements of this hypothesis have been supported by prior experiments, the links between complex spikes, simple spike plasticity, and behavior have not yet been examined simultaneously during the learning process. We now pioneer a trial-by-trial analysis of Purkinje cell responses in awake-behaving monkeys, with results that strongly favor a causal role for complex spikes in the induction of cerebellar plasticity during a simple motor learning task. We show that the presence of a complex spike on one learning trial is linked to a substantial depression of simple spike responses on the subsequent trial, at a time when behavioral learning is expressed.
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作者：
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通讯作者：
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