Clinical Targeting of Altered Metabolism in High-Grade Glioma.
Clinical Targeting of Altered Metabolism in High-Grade Glioma.
复制标题
高级别胶质瘤代谢改变的临床靶向治疗。
DOI：
10.1097/ppo.0000000000000550
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发表时间：
2021-09-01
期刊：
影响因子：
--
通讯作者：
Wahl DR
中科院分区：
文献类型：
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作者：
Scott AJ;Lyssiotis CA;Wahl DR
高级别胶质瘤是所有癌症中最致命的一种，尽管有标准的治疗方法，但需要新的治疗策略来改善患者的预后。用传统的化疗药物靶向改变肿瘤的代谢状态有成功的历史，在过去的二十年里，我们对细胞代谢的理解增加了脑肿瘤新代谢疗法的概念。在这里，我们强调了晚期胶质瘤的代谢改变及其转化为临床试验，使用新的药物和已经建立的药物重新用于癌症治疗，以改善这些致命疾病的结果。
High grade gliomas are among the deadliest of all cancers despite standard treatments, and new therapeutic strategies are needed to improve patient outcome. Targeting the altered metabolic state of tumors with traditional chemotherapeutic agents has a history of success, and our increased understanding of cellular metabolism in the past two decades has reinvigorated the concept of novel metabolic therapies in brain tumors. Here we highlight metabolic alterations in advanced gliomas and their translation into clinical trials using both novel agents and already established drugs repurposed for cancer treatment in an effort to improve outcome for these deadly diseases.