Transformation of reactive isochromenylium intermediates to stable salts and their cascade reactions with olefins.
Transformation of reactive isochromenylium intermediates to stable salts and their cascade reactions with olefins.
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DOI：
10.1021/ol9019524
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发表时间：
2009-09
期刊：
影响因子：
5.2
通讯作者：
Zhi-Long Hu;Wenjian Qian;Sheng Wang;Shaozhong Wang;Z. Yao
中科院分区：
文献类型：
--
作者：
Zhi-Long Hu;Wenjian Qian;Sheng Wang;Shaozhong Wang;Z. Yao
实现了反应性异铬中间体向相应的可储存和稳定试剂的转化，并方便地制备和表征了多种异铬四氟硼酸盐(ICTB，1)。通过温和的级联反应，异铬酸四氟硼酸盐1a与烯烃的直接无金属处理得到了各种多环骨架4。从预官能化邻炔基苯甲醛出发，发展了一锅无金属的分子内级联环化反应，合成了2，3-二氢菲-4(1H)-酮类化合物。
Transformation of reactive isochromenylium intermediates to the corresponding storable and stable reagents has been achieved, and a number of isochromenylium tetrafluoroborates (ICTBs, 1) have been conveniently prepared and characterized. Direct metal-free treatment of isochromenylium tetrafluoroborate 1a with olefins afforded a variety of polycyclic frameworks 4 via mild cascade reactions. Starting from the prefunctionalized o-alkynylbenzaldehydes, a one-pot metal-free procedure of intramolecular cascade annulation to 2,3-dihydrophenanthren-4(1H)-one derivatives was also developed.