Ion-Mobility-Derived Collision Cross Section as an Additional Identification Point for Multiresidue Screening of Pesticides in Fish Feed
Ion-Mobility-Derived Collision Cross Section as an Additional Identification Point for Multiresidue Screening of Pesticides in Fish Feed
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DOI：
10.1021/acs.analchem.6b03381
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发表时间：
2016-11-15
影响因子：
7.4
通讯作者：
Berntssen, Marc H. G.
中科院分区：
文献类型：
--
作者：
Regueiro, Jorge;Negreira, Noelia;Berntssen, Marc H. G.
离子迁移谱法允许测量碰撞横截面（CCS），它提供了有关气相离子分子形状的信息。尽管行波离子迁移率谱法（TWIMS）与高分辨率四极杆飞行时间质谱法（QTOFMS）的结合主要用于结构解析，但其在复杂样品中快速筛选小分子的潜力尚未得到充分评估。目前的工作是探索超高效液相色谱（UHPLC）结合新设计的TWIMS-QTOFMS在复杂鲑鱼饲料基质中筛选和鉴定大量农药的能力。现提供一个包含twims衍生的200多种农药的CCS值的数据库。CCS测量显示出较高的日内和日间重复性（RSD < 1%），并且不受所研究矩阵复杂性的影响（Delta CCS）
Ion mobility spectrometry allows for the measurement of the collision cross section (CCS), which provides information about the shape of an ionic molecule in the gas phase. Although the hyphenation of traveling-wave ion mobility spectrometry (TWIMS) with high-resolution quadrupole time-of-flight mass spectrometry (QTOFMS) has been mainly used for structural elucidation purposes, its potential for fast screening of small molecules in complex samples has not yet been thoroughly evaluated. The current work explores the capabilities of ultrahigh-performance liquid chromatography (UHPLC) coupled to a new design TWIMS-QTOFMS for the screening and identification of a large set of pesticides in complex salmon feed matrices. A database containing TWIMS-derived CCS values for more than 200 pesticides is hereby presented. CCS measurements showed high intra- and interday repeatability (RSD < 1%), and they were not affected by the complexity of the investigated matrices (Delta CCS