Simultaneous whole-body time-of-flight 18F-FDG PET/MRI: a pilot study comparing SUVmax with PET/CT and assessment of MR image quality.
Simultaneous whole-body time-of-flight 18F-FDG PET/MRI: a pilot study comparing SUVmax with PET/CT and assessment of MR image quality.
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DOI：
10.1097/rlu.0000000000000611
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发表时间：
2015-01
影响因子：
10.6
通讯作者：
Zaharchuk G
中科院分区：
文献类型：
--
作者：
Iagaru A;Mittra E;Minamimoto R;Jamali M;Levin C;Quon A;Gold G;Herfkens R;Vasanawala S;Gambhir SS;Zaharchuk G
最近在临床实践中引入的混合PET/MRI扫描仪在几种临床情况下显示出有希望的初步结果。然而，第一代组合PET/MRI缺乏飞行时间（TOF）技术。在这里，我们报告的结果，第一个病人进行扫描的一个全新的完全集成的PET/MRI扫描仪与TOF。我们分析了来自接受临床指征18F FDG PET/CT，随后进行PET/MRI的患者的数据。通过18F FDG PET/MRI和18F FDG PET/CT测量病变、小脑、唾液腺、肺、主动脉弓、肝、脾、骨骼肌和脂肪的最大标准化摄取值（SUVmax）。两名经验丰富的放射科医生独立审查了MR数据的图像质量。36例患者（19例男性，17例女性，平均[±标准差]年龄为61 ± 14岁[范围：27-86岁]）共69处离散病变符合入选标准。在注射10 ± 1 mCi（范围：8-12 mCi）18 F FDG后，在平均（±标准差）74 ± 14分钟（范围：49-100分钟）时采集PET/CT图像。PET/MRI扫描在18F FDG注射后161 ± 29分钟（范围：117 - 286分钟）开始。在PET/CT的PET上识别的所有病变也在PET/MRI的PET上看到。对于所有病变，PET/MRI的平均SUVmax值均高于PET/CT。未观察到MR图像质量下降。到目前为止，使用该试验用PET/MR系统获得的数据表明，TOF PET系统能够在常规脉冲序列的同步PET/MR过程中具有出色的性能。磁共振成像未受损。PET/CT和PET/MRI的PET图像比较显示，后者的图像质量没有损失。这些结果支持进一步研究这种新型的完全集成的TOF PET/MRI仪器。
The recent introduction of hybrid PET/MRI scanners in clinical practice has shown promising initial results for several clinical scenarios. However, the first generation of combined PET/MRI lacks time-of-flight (TOF) technology. Here we report the results of the first patients to be scanned on a completely novel fully integrated PET/MRI scanner with TOF. We analyzed data from patients who underwent a clinically indicated 18F FDG PET/CT, followed by PET/MRI. Maximum standardized uptake values (SUVmax) were measured from 18F FDG PET/MRI and 18F FDG PET/CT for lesions, cerebellum, salivary glands, lungs, aortic arch, liver, spleen, skeletal muscle, and fat. Two experienced radiologists independently reviewed the MR data for image quality. Thirty-six patients (19 men, 17 women, mean [±standard deviation] age of 61 ± 14 years [range: 27–86 years]) with a total of 69 discrete lesions met the inclusion criteria. PET/CT images were acquired at a mean (±standard deviation) of 74 ± 14 minutes (range: 49–100 minutes) after injection of 10 ± 1 mCi (range: 8–12 mCi) of 18F FDG. PET/MRI scans started at 161 ± 29 minutes (range: 117 – 286 minutes) after the 18F FDG injection. All lesions identified on PET from PET/CT were also seen on PET from PET/MRI. The mean SUVmax values were higher from PET/MRI than PET/CT for all lesions. No degradation of MR image quality was observed. The data obtained so far using this investigational PET/MR system have shown that the TOF PET system is capable of excellent performance during simultaneous PET/MR with routine pulse sequences. MR imaging was not compromised. Comparison of the PET images from PET/CT and PET/MRI show no loss of image quality for the latter. These results support further investigation of this novel fully integrated TOF PET/MRI instrument.