Intercellular junctions in hepatocellular carcinoma.
Intercellular junctions in hepatocellular carcinoma.
复制标题
肝细胞癌的细胞间连接。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
R. Rowland
中科院分区：
文献类型：
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作者：
Swift Jg;Mukherjee Tm;R. Rowland
冻裂技术被用于研究两例肝细胞癌细胞间连接的组织。一例无肿瘤肝硬化已纳入比较。肝细胞癌肿瘤细胞紧密连接紊乱。紧密的连接网络通常不平行于管腔定向。在一些区域，紧密连接由2到4条链组成，而在其他区域，它们被减少到一条链。紧密连接的不连续性和局部增生也可见。一些紧密连接由膜内颗粒排列形成不连续的网络组成。肿瘤细胞间的间隙连接小且少见。间隙连接仅在侧质膜上发现，而在紧密连接网络中未见。这些发现被解释为表明在肝细胞癌中细胞间通讯的改变，以及肝细胞分化紧密连接的能力的改变。
The freeze-fracture technique has been used to study the organization of intercellular junctions in two cases of hepatocellular carcinoma. A tumor free cirrhotic liver has been included for comparison. Tight junctions were disorganized in the tumor cells of hepatocellular carcinoma. The tight junction networks often were not orientated parallel to the canalicular lumen. In some areas tight junctions comprised 2 to 4 strands, while in other areas they were reduced to a single strand. Discontinuities and local proliferation of tight junctions were also seen. Some tight junctions were composed of intramembrane particles aligned to form a discontinuous network. Gap junctions between the tumor cells were small and infrequent. Gap junctions were found only on the lateral plasma membranes and were not seen within the tight junction networks. These findings have been interpreted to indicate changes in intercellular communication, and an alteration in the ability of hepatocytes to differentiate tight junctions in hepatocellular carcinoma.