Early- and late-onset startle modulation in unipolar depression
Early- and late-onset startle modulation in unipolar depression
复制标题
DOI：
10.1111/j.1469-8986.00162.x
复制
发表时间：
2004-05-01
期刊：
影响因子：
3.7
通讯作者：
Sutton, SK
中科院分区：
文献类型：
--
作者：
Dichter, GS;Tomarken, AJ;Sutton, SK
在两个实验阶段。我们评估了非抑郁受试者和单极抑郁受试者的早发型和晚发型声音惊吓眨眼调制和情感图片的主观评级。抑郁的参与者进行了评估之前和之后的抗抑郁药物安非他酮SR治疗。抑郁和非抑郁的参与者表现出觉醒依赖性惊吓调制早期探头发生图片发病后300毫秒。非抑郁的参与者表现出预期的价依赖性惊吓调制后期探测（发病后3500 - 4500英寸）。与此相反，抑郁症患者的后期探测眨眼幅度无关的图片效价。这种组间差异模式不受给药调节。在图片的自我报告评分方面，组间没有差异。这些结果表明，抑郁症的特点可能是异常反应的情感刺激和惊吓调制可以是一个更敏感的指标与抑郁症的情感反应赤字比自我报告的措施。
In two experimental sessions. we assessed early- and late-onset acoustic startle eyeblink modulation and subjective ratings of emotional pictures by nondepressed participants and by unipolar depressed participants. Depressed participants were assessed before and after treatment with the antidepressant medication Bupropion SR. Both depressed and nondepressed participants exhibited arousal-dependent startle modulation to early probes occurring 300 ms after picture onset. Nondepressed participants demonstrated the expected valence-dependent startle modulation to late probes (3,500-4,500 ins post-onset). In contrast, the late-probe blink magnitudes of depressed patients were unrelated to picture valence. This pattern of group differences was not moderated by treatment. There were no between-group differences in self-report ratings to pictures. These results suggest that depression may be characterized by anomalous responses to affective stimuli and that startle modulation can be a more sensitive index of affective response deficits linked to depression than self-report measures.