[Exploring study on the cutoff of vitamin D deficiency in Chinese adults].
[Exploring study on the cutoff of vitamin D deficiency in Chinese adults].
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DOI：
10.19813/j.cnki.weishengyanjiu.2020.05.001
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发表时间：
2020-09-01
期刊：
影响因子：
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通讯作者：
Yang, Lichen
中科院分区：
文献类型：
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作者：
Hu, Yichun;Li, Siran;Yang, Lichen
目的：研究中国18-44岁非临床人群25-羟基维生素D [25（OH）D]浓度与全段甲状旁腺激素（iPTH）浓度的关系，探讨维生素D适宜营养状态的判定阈值。方法：从已建立的'中国慢性病与营养调查生物样本库（CCDNS，2015-2018）中选取650例18-44岁成人血浆样本。采用问卷调查的方式收集基本信息（包括年龄、性别、地区类型、季节等），统一测定受试者的腰围、身高和体重。秦岭和淮河将南北地区分割开来。采用高效液相色谱-串联质谱法测定血清25（OH）D浓度，采用电子化学发光法测定iPTH。用偏相关分析法分析25（OH）D与iPTH的关系，用局部加权散点图平滑法分析25（OH）D阈值，并按年龄、采血季节、BMI、腰围、性别、纬度等因素调整iPTH。在排除血液样本质量较差的样本后，共分析了623份血清样本（293名男性，330名女性）的25（OH）D浓度和iPTH浓度。25（OH）D浓度男性显著高于女性（P0. 05）。0001）。25（OH）D浓度在中国南方高于北方（P0. 05）。0001）。25（OH）D浓度秋季高于春季和冬季（P0. 05）。0001）。25（OH）D浓度城市低于农村（P=0. 05）。018）。当25（OH）D低于17时，观察到25（OH）D浓度与iPTH浓度之间呈负相关。两种性别均为6 ng/mL。男性25（OH）D的阈值为16。2 ng/mL，为25.结论：中国18-44岁成人25（OH）D与iPTH的阈值及相关性存在性别差异。需要进一步研究来评估最佳维生素D的性别特异性范围。
OBJECTIVE: To study the relationship between 25-hydroxyvitamin D [25(OH)D] concentration and intact parathyroid hormone(iPTH) concentration in the Chinese non-clinical population aged 18-44 y, and to explore the threshold value of determining the appropriate nutritional status of vitamin D.METHODS: A total of 650 plasma samples of adults aged 18-44 years old were selected from the established biological samples' bank of Chinese Chronic Diseases and Nutrition Survey(CCDNS, 2015-2018). Basic information(including age, gender, region type, season, etc. ) was collected by questionnaires, and the waist circumference, height and weight of the subjects were determined unified. North and South area was divided by Qinling Mountains and Huaihe River. The serum 25(OH)D concentration was determined by high performance liquid chromatography tandem mass spectrometer, and the iPTH was determined by electronic chemiluminescence method. The relationship of 25(OH)D and iPTH were analyzed by partial correlation analysis, and the threshold of 25(OH)D was analyzed by locally weighted scatter plot smoothing method after adjusting the iPTH by age, season of blood draw, BMI, waist, sex and latitude.RESULTS: A total of 623 serum samples(293 male, 330 female) of 25(OH)D concentration and iPTH concentration were analyzed after excluding samples with poor blood sample quality. Significant higher 25(OH)D concentration was found in male than female(P<0. 0001). And the samples from the southern China had higher 25(OH)D concentration than those from the northern China(P<0. 0001). Samples from autumn had higher 25(OH)D concentration than those from spring and winter(P<0. 0001). The 25(OH)D concentration of samples from cities was lower than that of rural areas(P=0. 018). The inversely relationship between 25(OH)D concentration and iPTH concentration was observed when the 25(OH)D was below 17. 6 ng/mL for both sexes. The threshold of 25(OH)D for male was 16. 2 ng/mL and it was 25. 6 ng/mL for female.CONCLUSION: The threshold and the relationship between 25(OH)D and iPTH differs by sex among Chinese adults aged 18-44 y. Further study is needed to evaluate the sex-specific ranges of optimal vitamin D.