Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts
Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts
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DOI：
10.1016/j.jbiotec.2006.03.044
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发表时间：
2006-08-05
影响因子：
4.1
通讯作者：
Fraaije, M. W.
中科院分区：
文献类型：
--
作者：
van Berkel, W. J. H.;Kamerbeek, N. M.;Fraaije, M. W.
在过去的几十年中，大量的黄素依赖性单加氧酶已被分离和研究。这表明，黄素蛋白单加氧酶能够催化各种各样的氧化反应，如区域选择性羟基化和对映选择性磺氧化。这些氧化反应如果不是不可能的话，通常很难使用化学方法实现。对现有基因组序列的分析表明，存在更多的黄素蛋白单加氧酶，并等待生物催化探索。基于已知的一些黄素蛋白单加氧酶的生化特性和序列和结构分析，黄素蛋白单加氧酶可以分为六个不同的黄素蛋白单加氧酶亚类。本文综述了属于这些不同酶亚类的已知黄素蛋白单加氧酶。此外，生物催化潜力的选定数量的黄素蛋白单加氧酶的突出。(c)2006 Elsevier B.V.保留所有权利。
During the last decades a large number of flavin-dependent monooxygenases have been isolated and studied. This has revealed that flavoprotein monooxygenases are able to catalyze a remarkable wide variety of oxidative reactions such as regioselective hydroxylations and enantioselective sulfoxidations. These oxidation reactions are often difficult, if not impossible, to be achieved using chemical approaches. Analysis of the available genome sequences has indicated that many more flavoprotein monooxygenases exist and await biocatalytic exploration. Based on the known biochemical properties of a number of flavoprotein monooxygenases and sequence and structural analyses, flavoprotein monooxygenases can be classified into six distinct flavoprotein monooxygenase subclasses. This review provides an inventory of known flavoprotein monooxygenases belonging to these different enzyme subclasses. Furthermore, the biocatalytic potential of a selected number of flavoprotein monooxygenases is highlighted. (c) 2006 Elsevier B.V. All rights reserved.