N-Heterocyclic carbene-catalyzed sulfa-Michael addition of enals
N-Heterocyclic carbene-catalyzed sulfa-Michael addition of enals
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N-杂环卡宾催化烯醛的磺胺-迈克尔加成
DOI：
10.1039/c7cc07269d
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发表时间：
2017
影响因子：
4.9
通讯作者：
He Lin
中科院分区：
文献类型：
--
作者：
Cong Zi Song;Li Yang Guo;Du Guang Fen;Gu Cheng Zhi;Dai Bin;He Lin
研究了一种高效的N-杂环卡宾（NHC）催化烯醛与硫醇的磺基迈克尔加成反应（SMA）。在10mol%稳定的游离卡宾IPr催化下，以20mol%六氟异丙醇（HFIP）为添加剂，烯醛与各种硫醇反应，得到SMA加合物，产率为54-98%。在这个过程中，自由卡宾优先与硫醇通过氢键相互作用，没有观察到NHC催化的扩展Umpolung转换。
An efficient N-heterocyclic carbene (NHC) catalyzed sulfa-Michael addition (SMA) between enals and thiols has been developed. Under the catalysis of 10 mol% stable free carbene IPr and with 20 mol% hexafluoroisopropanol (HFIP) as an additive, enals react with a variety of thiols to afford the SMA adducts in 54–98% yields. In this process, the free carbene preferentially interacts with thiols through hydrogen-bonding and no NHC-catalyzed extended Umpolung transformations were observed.