MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions
MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions
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DOI：
10.1038/sj.neo.7900244
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发表时间：
2002-07-01
期刊：
影响因子：
4.8
通讯作者：
Chance, B
中科院分区：
文献类型：
--
作者：
Ntziachristos, V;Yodh, AG;Chance, B
我们提出了一种新的混合系统，结合磁共振成像（MRI）和近红外（NIR）光学测量乳腺癌在体内的非侵入性研究的临床实施。使用MR-NIR原型成像仪和光谱仪对14名患者进行了研究。扩散光学层析成像方案采用MR图像作为先验信息来实现图像引导的NIR局部光谱方案。所有进入研究的患者还接受了钆增强MRI和活检，以便与MR读数和组织病理学交叉验证光学结果。该技术量化了体内5个恶性和9个良性乳腺病变的氧合血红蛋白和脱氧血红蛋白。乳腺癌患者的血氧饱和度较低，血药浓度高于大多数良性病变。癌症的平均血红蛋白浓度（[H]）为0.130+/-0.100 mM，平均血红蛋白饱和度（Y）为60+/-9%，而背景组织的[H]=0.018+/-0.005 mM，Y=69+/-6%。纤维腺瘤表现出高血红蛋白浓度[H]=0.060+/-0.010 mM和氧饱和度轻度降低Y=67+/-2%。囊肿和其他正常病变很容易区分的基础上内在的对比信息。这种新的光学技术可以是MR检查中的重要附加设备，并可用于表征具有诊断和治疗预后潜力的癌症的功能参数。可以预见，该技术可以发挥重要作用，在大脑和肌肉的功能激活研究以及。
We present the clinical implementation of a novel hybrid system that combines magnetic resonance imaging (MRI) and near-infrared (NIR) optical measurements for the noninvasive study of breast cancer in vivo. Fourteen patients were studied with a MR-NIR prototype imager and spectrometer. A diffuse optical tomographic scheme employed the MR images as a priori information to implement an image-guided NIR localized spectroscopic scheme. All patients who entered the study also underwent gadolinium-enhanced MRI and biopsy so that the optical findings were cross-validated with MR readings and histopathology. The technique quantified the oxy- and deoxyhemoglobin of five malignant and nine benign breast lesions in vivo. Breast cancers were found with decreased oxygen saturation and higher blood concentration than most benign lesions. The average hemoglobin concentration ([H]) of cancers was 0.130+/-0.100 mM, and the average hemoglobin saturation (Y) was 60+/-9% compared to [H]=0.018+/-0.005 mM and Y=69+/-6% of background tissue. Fibroadenomas exhibited high hemoglobin concentration [H]=0.060+/-0.010 mM and mild decrease in oxygen saturation Y=67+/-2%. Cysts and other normal lesions were easily differentiated based on intrinsic contrast information. This novel optical technology can be a significant add-on in MR examinations and can be used to characterize functional parameters of cancers with diagnostic and treatment prognosis potential. It is foreseen that the technique can play a major role in functional activation studies of brain and muscle as well.