Magnetic capture of superparamagnetic nanoparticles in a constant pressure microcapillary flow
Magnetic capture of superparamagnetic nanoparticles in a constant pressure microcapillary flow
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DOI：
10.1016/j.jmmm.2009.02.088
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发表时间：
2009-05
影响因子：
2.7
通讯作者：
N. Darton;B. Hallmark;T. A. James;Pulkit Agrawal;M. Mackley;N. Slater
中科院分区：
文献类型：
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作者：
N. Darton;B. Hallmark;T. A. James;Pulkit Agrawal;M. Mackley;N. Slater
合成了超顺磁性纳米粒子，并在透明、塑料和微毛细管阵列（微毛细管膜或MCF）内研究了其流动磁性捕获行为。该系统代表了毛细血管系统的体外模拟物，便于捕获现象的简单光学观察。在恒定压力下将纳米颗粒的分散体递送至位于0.5T永磁体附近的毛细管阵列。分析了捕获的纳米颗粒相对于磁体位置的空间位置。纳米颗粒捕获的位置似乎取决于空间位置和流体流速，并表明在磁场中的两个区域，其中纳米颗粒的作用不同;一个“转向”区和一个“捕获”区。
Superparamagnetic nanoparticles were synthesised and their in-flow magnetic capture behaviour studied within transparent, plastic, and microcapillary arrays (microcapillary film or MCF). This system represents an in vitro analogue of capillary vasculature and facilitates easy optical observation of capture phenomenon. A dispersion of nanoparticles was delivered at a constant pressure to an array of capillaries sited adjacent to a 0.5T permanent magnet. The spatial position of trapped nanoparticles relative to the position of the magnet was analysed. The position of nanoparticle capture appears to be dependent on both spatial location and fluid flow rate and suggests two zones in the magnetic field in which nanoparticles are acted upon differently; a ‘steering’ zone and a ‘capture’ zone.