Progranulin Mutations Affects Brain Oscillatory Activity in Fronto-Temporal Dementia
Progranulin Mutations Affects Brain Oscillatory Activity in Fronto-Temporal Dementia
复制标题
颗粒体蛋白前体突变影响额颞叶痴呆的大脑振荡活动
DOI：
--
复制
发表时间：
2016
影响因子：
4.8
通讯作者：
R. Ghidoni
中科院分区：
文献类型：
--
作者：
D. Moretti;L. Benussi;Silvia Fostinelli;M. Ciani;G. Binetti;R. Ghidoni
背景：轻度认知障碍(MCI)是痴呆的前驱症状的临床阶段。这一实用概念也可用于额颞部痴呆(FTD)。近年来，原颗粒蛋白(PGRN)被认为是由GRN零突变引起的额颞叶退行性变(FTLD)的一种有用的生物标志物。脑电(EEG)是检测大脑网络变化的可靠工具。本研究的工作假设是，脑电振荡可以检测到不同FTLD分期(FTD-MCI与显性FTD)之间的不同修改，以及显性FTD患者GRN突变携带者与非携带者之间的差异。材料和方法：对所有患者进行脑电检查，对FTD明确的患者行PGRN剂量检测。采用简易精神状态检查量表(MMSE)对其认知状态进行调查。结果：与显性FTD相比，MCI-FTD在α振荡和theta振荡中的频谱功率均显著降低。与非携带者相比，受FTLD影响的GRN突变携带者表现出高α值增加和theta振荡减少。结论：脑电频率节律对FTD的不同阶段敏感，可检测GRN突变对脑振荡活动的影响。
Background: Mild cognitive impairment (MCI) is a clinical stage indicating a prodromal phase of dementia. This practical concept could be used also for fronto-temporal dementia (FTD). Progranulin (PGRN) has been recently recognized as a useful diagnostic biomarker for fronto-temporal lobe degeneration (FTLD) due to GRN null mutations. Electroencephalography (EEG) is a reliable tool in detecting brain networks changes. The working hypothesis of the present study is that EEG oscillations could detect different modifications among FTLD stages (FTD-MCI versus overt FTD) as well as differences between GRN mutation carriers versus non-carriers in patients with overt FTD. Materials and Methods: EEG in all patients and PGRN dosage in patients with a clear FTD were detected. The cognitive state has been investigated through mini mental state examination (MMSE). Results: MCI-FTD showed a significant lower spectral power in both alpha and theta oscillations as compared to overt FTD. GRN mutations carriers affected by FTLD show an increase in high alpha and decrease in theta oscillations as compared to non-carriers. Conclusion: EEG frequency rhythms are sensible to different stage of FTD and could detect changes in brain oscillatory activity affected by GRN mutations.
影响因子：
9.9
作者：
R. Faber
通讯作者：
R. Faber
影响因子：
2.5
作者：
Raghavachari, S;Lisman, JE;Kahana, MJ
通讯作者：
Kahana, MJ
影响因子：
14.5
作者：
Rascovsky, Katya;Hodges, John R.;Miller, Bruce L.
通讯作者：
Miller, Bruce L.