Are there any functional differences of the enteric nervous system between the right-sided diverticular colon and the left-sided diverticular colon? An in vitro study
Are there any functional differences of the enteric nervous system between the right-sided diverticular colon and the left-sided diverticular colon? An in vitro study
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右侧憩室结肠和左侧憩室结肠的肠神经系统功能是否存在差异？
DOI：
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发表时间：
2014
影响因子：
2.8
通讯作者：
R. Tomita
中科院分区：
文献类型：
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作者：
R. Tomita
目的比较右侧结肠憩室（RCD）和左侧结肠憩室（LCD）患者肠神经系统（ENS）功能的差异。作为对照，22例右侧正常结肠（RNC）标本来自22例结肠癌。从24例结肠癌中获取24例左侧正常结肠（LNC）标本。结果在阻断肾上腺素能神经和胆碱能神经前，憩室结肠经胆碱能神经收缩的发生率明显高于正常结肠，而在阻断肾上腺素能神经和胆碱能神经后，结肠经胆碱能神经收缩的发生率明显高于正常结肠（右侧结肠; p = 0.0022，左侧结肠; p < 0.0001）。RNC和LNC之间（p = 0.3606）以及RCD和LCD之间（p = 0.7684）无显著差异。阻断肾上腺素能和胆碱能神经后，正常结肠中通过非肾上腺素能非胆碱能抑制（NANC）神经的松弛发生率显著高于憩室结肠（右侧结肠; p = 0.0435，左侧结肠; p = 0.0034）。RNC与LNC（p = 0.2909）、RCD与LCD（p = 0.9464）之间无显著性差异。双侧正常结肠NANC抑制神经明显多于双侧憩室结肠。RCD和LCD之间ENS的功能也没有差异。
PurposeTo evaluate functional differences of the enteric nervous system (ENS) in patients between right-side colonic diverticula (RCD) and left-sided colonic diverticula (LCD), the author compared the ENS responses between RCD and LCD.MethodsTen specimens were obtained from 10 patients with RCD, and 16 specimens were taken from 16 LCD. As a control, twenty-two specimens of right-sided normal colon (RNC) were obtained from 22 colonic cancers. Twenty-four specimens of left sided normal colon (LNC) were obtained from 24 colonic cancers. A mechanography was used to evaluate in vitro muscle responses to electrical field stimulation (EFS) before and after treatment with various autonomic nerve blockers.ResultsBefore blockade of the adrenergic and cholinergic nerves, the incidences of contraction via cholinergic nerve in the colons with diverticula were significantly greater than those in the normal colons (right-sided colon; p = 0.0022, left-sided colon; p < 0.0001). There were no significant differences between RNC and LNC (p = 0.3606), and between RCD and LCD (p = 0.7684). After the blockade of adrenergic and cholinergic nerves, the incidence of relaxation via non-adrenergic non-cholinergic inhibitory (NANC) nerve in the normal colons was significantly greater than that in the diverticular colons (right-sided colon; p = 0.0435, left-sided colon; p = 0.0034). There were no significant differences between RNC and LNC (p = 0.2909) and between RCD and LCD (p = 0.9464).ConclusionCholinergic nerves were dominant in bilateral diverticular colon compared with bilateral normal colon. NANC inhibitory nerves were dominant in bilateral normal colon compared with bilateral diverticular colon. There were also no functional differences of the ENS between RCD and LCD.