ENDOGENOUS ADENOSINE MODULATES LONG-TERM POTENTIATION IN THE HIPPOCAMPUS
ENDOGENOUS ADENOSINE MODULATES LONG-TERM POTENTIATION IN THE HIPPOCAMPUS
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DOI：
10.1016/0306-4522(94)90373-5
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发表时间：
1994-09-01
期刊：
影响因子：
3.3
通讯作者：
RIBEIRO, JA
中科院分区：
文献类型：
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作者：
DEMENDONCA, A;RIBEIRO, JA
我们在大鼠海马切片上研究了内源性腺苷对记录在CA1区的Schaffer纤维刺激引起的频率诱导的长时程增强反应的影响。选择性A(1)腺苷受体拮抗剂1,3-二丙基-8-环戊基黄嘌呤（10-20 nM）的存在促进了长时程增强，而腺苷摄取阻滞剂硝基苄基硫代肌苷（5 μ M）的存在降低了长时程增强，这表明内源性腺苷通过腺苷A(1)受体介导对长时程增强发挥了强直抑制作用。我们还发现，选择性A(2)受体激动剂CGS 21680 （30 nM）存在时，长期增强作用增强，这表明腺苷A(2)受体的激活可能对长期增强有兴奋作用。我们认为，内源性腺苷能够调节突触可塑性的机制，如海马的长期增强。
The effect of endogenous adenosine on frequency-induced long-term potentiation of the responses evoked by stimulation of the Schaffer fibres and recorded in the CA1 area was studied in hippocampal slices of the rat. Long-term potentiation was facilitated in the presence of the selective A(1) adenosine receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine (10-20 nM), and was reduced in the presence of the adenosine uptake blocker, nitrobenzylthioinosine (5 mu M), suggesting that endogenous adenosine exerted a tonic inhibitory role on long-term potentiation, which was mediated through adenosine A(1) receptors. We also found that long-term potentiation was increased in the presence of the selective A(2) receptor agonist, CGS 21680 (30 nM), suggesting that the activation of adenosine A(2) receptors may have excitatory effects on long-term potentiation.We suggest that, endogenous adenosine is able to modulate mechanisms of synaptic plasticity, such as long-term potentiation, in the hippocampus.