Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain
Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain
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DOI：
10.1002/ptr.2142
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发表时间：
2007-07-01
影响因子：
7.2
通讯作者：
Chrubasik, S.
中科院分区：
文献类型：
--
作者：
Chrubasik, J. E.;Roufogalis, B. D.;Chrubasik, S.
草药治疗在欧洲非常流行。为了获得口服草药治疗关节或下腰痛有效的证据，检索Ovid(MEDLINE)、PubMed和Cochrane协作库，以进行系统评价。有效性的证据水平被定义为强-至少两项验证性研究证明了临床相关效果，中等-一项具有临床相关效果的验证性研究和/或多项高质量的探索性研究；否则，在发现不一致的情况下证据不足或相互矛盾。有强有力的证据表明，专利的不皂化鳄梨大豆提取物和哈帕根制剂每天含有50毫克的哈帕苷，对于生姜和专有的玫瑰果籽粉，效果适中，不足以用于博斯韦利亚锯齿胶树脂和其他草本制剂，对于专有的柳树皮提取物则不一致。需要进行更严格的研究，以证实草药在治疗骨关节炎和慢性下腰痛中的有效性，以便使该草药能够被纳入治疗指南。版权所有(C)2007 John Wiley&Sons，Ltd.
Treatment with herbal medicines is very popular in Europe. In order to get information on the evidence of effectiveness of oral herbal medicines in the treatment of pain in the joints or lower back, OVID(MEDLINE), PUBMED and COCHRANE COLLABORATION LIBRARY were searched back to 1985 for systematic reviews. The level of evidence of effectiveness was defined as strong - at least two confirmatory studies demonstrating a clinical relevant effect, moderate - one confirmatory study with a clinical relevant effect and/ or multiple exploratory studies of good quality; otherwise the evidence was insufficient or conflicting in the case of inconsistent findings.Fifteen systematic reviews were identified. The evidence of effectiveness was strong for a proprietary unsaponiflable avocado soybean fraction and Harpagophytum preparations containing >50 mg harpagoside in the daily dosage, moderate for ginger and a proprietary rose hip and seed powder, insufficient for Boswellia serrata gum resin and other herbal preparations and inconsistent for a proprietary willow bark extract.Further rigorous studies are required to confirm the usefulness of herbal medicines in the treatment of osteoarthritic complaints and chronic low back pain in order to enable acceptance of the herbal medicines into the treatment guidelines. Copyright (C) 2007 John Wiley & Sons, Ltd.