An update on the genetics of Gilles de la Tourette syndrome
An update on the genetics of Gilles de la Tourette syndrome
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DOI：
10.1016/s0022-3999(02)00586-x
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发表时间：
2003-07-01
影响因子：
4.7
通讯作者：
Pauls, DL
中科院分区：
文献类型：
--
作者：
Pauls, DL
目的：总结目前表明抽动秽语综合征（GTS）是遗传性的数据。研究方法：本文对GTS的家系研究、分离分析、候选基因研究和连锁研究等方面的文献进行了综述。结果与结论：有大量的数据表明：（1）遗传因素在GTS的表现中起重要作用;（2）几个基因是重要的，其中一些可能具有主要作用;（3）基因组的几个区域已被确定为这些易感基因的潜在位置。(C)2003年爱思唯尔公司All rights reserved.
Objectives: To summarize the current data suggesting that Gilles de la Tourette syndrome (GTS) is inherited and genetic. Methods: The extant literature on family studies, segregation analyses, candidate genes studies and linkage studies of GTS was reviewed and summarized. Results and conclusions: There is considerable data that suggests that: (1) genetic factors play an important role in the manifestation of GTS; (2) several genes are important with some possibly having major effect; and (3) several regions of the genome have been identified as potential locations of these susceptibility genes. (C) 2003 Elsevier Inc. All rights reserved.