Pentoxifylline reduces fibrin deposition and prolongs survival in neonatal hyperoxic lung injury.
Pentoxifylline reduces fibrin deposition and prolongs survival in neonatal hyperoxic lung injury.
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己酮可可碱可减少新生儿高氧性肺损伤的纤维蛋白沉积并延长生存期。
DOI：
10.1152/japplphysiol.00452.2004
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Walther,FransJ
中科院分区：
文献类型：
--
作者：
terHorst,SimoneAJ;Wagenaar,GerryTM;deBoer,Eveline;vanGastelen,MargôtA;Meijers,JoostCM;Biemond,BartJ;Poorthuis,BenJHM;Walther,FransJ
尽管治疗方式有所改善，支气管肺发育不良仍是早产儿死亡和发病的主要原因。己酮可可碱是一种磷酸二酯酶抑制剂，可抑制导致新生儿高氧性肺损伤的多种过程，包括炎症、凝血和水肿。使用早产大鼠模型，我们研究了己酮可可碱对高氧诱导的肺损伤和存活的影响。将早产大鼠幼仔暴露于100%氧气中，并皮下注射0.9%盐水或75 mg/kg己酮可可碱，每天两次。第10天，收获肺组织用于组织学、纤维蛋白沉积和mRNA表达，并收集支气管肺泡灌洗液用于总蛋白浓度。与未治疗的高氧暴露对照相比，己酮可可碱治疗使肺匀浆中的平均生存期延长了 3 天（P=0.0018），纤维蛋白沉积减少了 66%（P<0.001）。肺匀浆中单核细胞趋化蛋白-1的表达降低，但两组中TNF-α、IL-6、基质金属蛋白酶-12、组织因子和纤溶酶原激活物抑制剂-1的表达相似。己酮可可碱组支气管肺泡灌洗液中的总蛋白浓度降低了33%（P=0.029）。己酮可可碱治疗可减少肺泡纤维蛋白沉积，并延长患有新生儿高氧性肺损伤的早产大鼠的存活率，这可能是通过减少毛细血管-肺泡蛋白渗漏来实现的。
Bronchopulmonary dysplasia is a leading cause of mortality and morbidity in preterm infants despite improved treatment modalities. Pentoxifylline, a phosphodiesterase inhibitor, inhibits multiple processes that lead to neonatal hyperoxic lung injury, including inflammation, coagulation, and edema. Using a preterm rat model, we investigated the effects of pentoxifylline on hyperoxia-induced lung injury and survival. Preterm rat pups were exposed to 100% oxygen and injected subcutaneously with 0.9% saline or 75 mg/kg pentoxifylline twice a day. Onday 10, lung tissue was harvested for histology, fibrin deposition, and mRNA expression, and bronchoalveolar lavage fluid was collected for total protein concentration. Pentoxifylline treatment increased mean survival by 3 days (P= 0.0018) and reduced fibrin deposition by 66% (P< 0.001) in lung homogenates compared with untreated hyperoxia-exposed controls. Monocyte chemoattractant protein-1 expression in lung homogenates was decreased, but the expressions of TNF-α, IL-6, matrix metalloproteinase-12, tissue factor, and plasminogen activator inhibitor-1 were similar in both groups. Total protein concentration in bronchoalveolar lavage fluid was decreased by 33% (P= 0.029) in the pentoxifylline group. Pentoxifylline treatment attenuates alveolar fibrin deposition and prolongs survival in preterm rat pups with neonatal hyperoxic lung injury, probably by reducing capillary-alveolar protein leakage.
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国家儿童健康和人类发展研究所新生儿网络的极低出生体重结果。
影响因子：
8
作者：
M. Hack;J. Horbar;M. Malloy;J. Tyson;Elizabeth C. Wright;L. Wright
通讯作者：
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影响因子：
3.3
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影响因子：
3.8
作者：
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影响因子：
8
作者：
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J. Lemons;C. Bauer;W. Oh;S. Korones;L. Papile;B. Stoll;J. Verter;M. Temprosa;L. Wright;R. Ehr
影响因子：
3.6
作者：
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通讯作者：
Tanswell, AK