Infection with Helicobacter bilis but not Helicobacter hepaticus was Associated with Extrahepatic Cholangiocarcinoma
Infection with Helicobacter bilis but not Helicobacter hepaticus was Associated with Extrahepatic Cholangiocarcinoma
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DOI：
10.1111/hel.12195
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发表时间：
2015-06-01
期刊：
影响因子：
4.4
通讯作者：
Torres, Javier
中科院分区：
文献类型：
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作者：
Segura-Lopez, Fany K.;Aviles-Jimenez, Francisco;Torres, Javier
背景与目的胆道癌或胆管细胞癌(CCA)是西方世界第六大胃肠道肿瘤病因，世界各地的死亡率各不相同，其中智利、泰国、日本和印度东北部的死亡率最高。CCA可能发生在瓦特的胆管、胆囊或壶腹；危险因素包括肥胖、产次、遗传背景、地理和环境因素。细菌感染引起的炎症反应可能在CCA的发病机制中起一定作用。在这项工作中，我们调查了墨西哥人群中肝外胆管细胞癌(ECCA)与伤寒沙门氏菌、肝包虫或胆汁杆菌感染之间的关系。结果胆汁幽门螺杆菌阳性者44例，对照组19例(P=0.002；OR2.83，95%CI1.49~5.32)，分部位分析发现胆汁幽门螺杆菌感染与胆总管肿瘤的发生显著相关(P=0.0005；OR3.56，95%CI1.77~7.17)。而肝炎组(17/103)与对照组(13/91)比较差异无统计学意义(P=0.82；OR=1.19，95%CI为0.54~2.60)。结论胆汁幽门螺杆菌感染与ECCA，尤其是胆总管肿瘤的发病无明显相关性，但与肝门螺杆菌和伤寒沙门氏菌均无明显相关性。
Background and AimsThe biliary tract cancer or cholangiocarcinoma (CCA) represents the sixth leading cause of gastrointestinal tumors in the Western world, and mortality varies across the world, with regions such as Chile, Thailand, Japan, and northeastern India presenting the highest rates. CCA may develop in the bile duct, gallbladder, or ampulla of Vater; and risk factors include obesity, parity, genetic background, geographical and environmental factors. Inflammation induced by bacterial infections might play a role in the pathogenesis of CCA. In this work, we investigated whether there is an association between extrahepatic cholangiocarcinoma (ECCA) and infection with S.typhi, H.hepaticus, or H.bilis in a Mexican population.MethodsA total of 194 patients were included and divided into 91 patients with benign biliary pathology (controls) and 103 with ECCA (cases). Tumor samples were taken during endoscopic retrograde cholangiopancreatography by biliary brushing, followed by DNA extraction and PCR testing for infections.ResultsWe found that 44/103 cases were positive for H.bilis, compared with 19/91 controls (p=0.002; OR 2.83, 95% CI 1.49-5.32), and when analyzed by sub-site, H.bilis infection was significantly more associated with cancer in the common bile duct (p=0.0005; OR 3.56, 95% CI 1.77-7.17). In contrast, H.hepaticus infection was not different between cases (17/103) and controls (13/91) (p=0.82; OR 1.19, 95% CI 0.54-2.60). None of the samples were positive for S.typhi infection.ConclusionIn conclusion, infection with H.bilis but neither H.Hepaticus nor S.typhi was significantly associated with ECCA, particularly with tumors located in the common bile duct.