Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length

DOI：

10.1159/000479972

发表时间：

2017-01-01

期刊：

OBESITY FACTS

影响因子：

3.6

通讯作者：

中科院分区：

医学3区

文献类型：

作者：

Himbert, Caroline;Thompson, Henry;Ulrich, Cornelia M.

背景：在肥胖者中检测到氧化应激、DNA修复和端粒完整性的标记物水平改变，这可能是肥胖相关疾病发病的基础。然而，这些影响是否会被有意的减肥逆转，还没有得到系统的审查。方法：在PubMed/Medline中检索到2388篇文章，其中21篇研究(随机对照试验(RCT)(n=10)和非随机干预研究(n=11))被归类为测试有意减肥对i)氧化应激(n=15)、ii)DNA修复(n=2)和iii)端粒长度(n=4)的影响。结果：在广泛的干预设计中，饮食、运动、手术、气球诱导的减肥方案减少了氧化应激措施。研究体重减轻后DNA修复能力或端粒长度作为终点的研究在数量上较少，分别得出的结果为零或不一致。结论：虽然这项系统性综述支持故意减肥在减少肥胖相关氧化应激中的作用，但尚不清楚这种影响是主要结果，还是肥胖相关胰岛素抵抗和/或慢性炎症改善的次要结果。尽管考虑到氧化应激的减少，故意减肥对DNA修复能力的影响是可以预料到的，但还需要进行更多的研究。体重减轻对端粒长度或DNA修复的不一致影响表明，需要重新评估干预设计和检测方法学，以明确解决这一问题。(C)2017年作者(S)发稿：S.Karger GmbH，Freiburg

Background: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. Methods: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4). Results: Across a broad range of intervention designs, diet-, exercise-, surgery-, balloon-induced weight loss regimens decreased oxidative stress measures. Studies investigating DNA repair capacity or telomere length as endpoints after weight loss were less common in number and yielded null or inconsistent results, respectively. Conclusion: While this systematic review supports a role for intentional weight loss in reducing obesity-associated oxidative stress, it is not clear whether the effects are primary outcomes or secondary to improvement in obesity-associated insulin resistance and/or chronic inflammation. Although the lack of effect of intentional weight loss on DNA repair capacity might be anticipated given that oxidative stress is reduced, additional studies are needed. The inconsistent effects of weight loss on telomere length or DNA repair suggest the need for a re-assessment of intervention designs and assay methodology to definitively address this topic. (c) 2017 The Author(s) Published by S. Karger GmbH, Freiburg

Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review

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