Plasma leptin levels in pigs with different leptin and leptin receptor genotypes.
Plasma leptin levels in pigs with different leptin and leptin receptor genotypes.
复制标题
具有不同瘦素和瘦素受体基因型的猪的血浆瘦素水平。
DOI：
10.1111/j.1439-0388.2007.00715.x
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
J. Estany
中科院分区：
文献类型：
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作者：
Marcel Amills;D. Villalba;M. Tor;A. Mercadé;David Gallardo;B. Cabrera;N. Jiménez;J. Noguera;Armand Sánchez;J. Estany
猪瘦素（Lep）基因外显子3的C3469T突变已经在不同的猪品种中进行了基因分型，但关于其与生长、肥胖和胴体性状的关系产生了有争议的结果。猪瘦素受体（Lepr）基因中的HpaII限制性片段长度多态性（RFLP）也有类似的报道，根据所采用的统计模型发现了关联。我们工作的主要目的是研究不同C3469T和麻风hpai RFLP基因型猪的血清瘦素浓度是否存在差异。为此，我们测量了68头不同麻风C3469T和麻风HpaII RFLP基因型的长白猪160天的血浆瘦素水平。Lep （TT: 11.68 ng/ml, TC: 10.71 ng/ml）和Lepr （AA: 12.6 ng/ml, AB: 10.93 ng/ml, BB: 11.74 ng/ml）基因型对血浆Lep浓度均无显著影响。此外，在320头长白猪的商业群体中，我们没有发现Lep和Lepr基因型与生长和肥胖性状表型变异之间的任何关联。
A C3469T mutation at exon 3 of the pig leptin (Lep) gene has been genotyped in diverse pig breeds yielding controversial results with regard to its association with growth, fatness and carcass traits. A similar situation has been reported for a HpaII restriction fragment length polymorphism (RFLP) in the pig leptin receptor (Lepr) gene, where associations were found depending on the statistical model employed. The main objective of our work was to investigate if leptin plasma concentrations differ in pigs with different C3469T and Lepr HpaII RFLP genotypes. With this aim, we have measured plasma leptin levels at 160 days in 68 Landrace pigs with different Lep C3469T and Lepr HpaII RFLP genotypes. Neither Lep (TT: 11.68 ng/ml, TC: 10.71 ng/ml) nor Lepr (AA: 12.6 ng/ml, AB: 10.93 ng/ml, BB: 11.74 ng/ml) genotypes influenced significantly plasma Lep concentration. Moreover, we did not find any association between Lep and Lepr genotypes and phenotypic variation at growth and fatness traits in a commercial population of 320 Landrace pigs.