Variability in biological monitoring of organic solvent exposure. II. Application of a population physiological model.
Variability in biological monitoring of organic solvent exposure. II. Application of a population physiological model.
复制标题
有机溶剂暴露的生物监测的变异性。
DOI：
10.1136/oem.46.8.547
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
W G Cumberland
中科院分区：
文献类型：
--
作者：
P O Droz;M M Wu;W G Cumberland
生理群体模型用于研究与溶剂暴露的生物监测相关的变异性。该模型由生理区室模型和统计模拟技术的组合组成。考虑的可变因素包括：暴露浓度、体力负荷、体型、肝功能和肾功能。该模型适用于六种溶剂：三氯乙烯、四氯乙烯、甲基氯仿、苯、甲苯和苯乙烯。将生物指标和空气监测作为外部和内部暴露的预测因子进行比较（摄取、大脑浓度、反应性代谢物形成）。看来最佳指标的选择取决于要预测的暴露类型。对环境、生理或代谢等各种因素的影响进行了量化和讨论。结果表明，暴露的波动对生物指示剂结果的最终变异性起着很大的作用。考虑对该群体模型的进一步改进和应用。
A physiological population model is used to study the variability associated with the biological monitoring of solvent exposure. The model consists of a combination of a physiological compartmental model and statistical simulation technique. Variable components considered are: exposure concentration, physical workload, body build, liver function, and renal function. The model is applied to six solvents: trichloroethylene, tetrachloroethylene, methylchloroform, benzene, toluene, and styrene. Biological indicators and air monitoring are compared as predictors of exposure, both external and internal (uptake, brain concentration, reactive metabolite formation). It appears that the choice of the best indicator depends on the type of exposure which is to be predicted. The effects of the various factors, environmental, physiological, or metabolic, are quantified and discussed. It is shown that fluctuation in exposure plays a large part in the final variability of biological indicator results. Further improvements and applications of this population model are considered.