Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study.
Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study.
复制标题
在第一集精神分裂症中，未经治疗的精神病和大脑功能的持续时间：一项近红外光谱研究。
DOI：
10.1038/srep18069
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发表时间：
2015-12-10
影响因子：
4.6
通讯作者：
Chan CH
中科院分区：
文献类型：
--
作者：
Chou PH;Lin WH;Lin CC;Hou PH;Li WR;Hung CC;Lin CP;Lan TH;Chan CH
精神分裂症（SZ）患者未经治疗的精神病（DUP）持续时间较长与临床结局较差相关;然而，尚不清楚这是否是由于精神病的神经毒性作用。本研究的目的是使用近红外光谱（NIRS）研究DUP对首次发作SZ（FES）患者两种语言流畅性测试（VFT）脑功能的影响。共有28名FES患者和29名健康对照（HC）在VFT期间接受了NIRS。使用双尾t检验和错误发现率方法对皮质活动进行组间比较。然后，我们检查了DUP和每个通道的血流动力学变化之间的关联，以确定DUP对大脑皮层活动的任何影响。在字母VFT，HC组表现出显着更大的皮质激活双侧额颞区相比，FES患者。然而，这种区别没有观察到，而执行类别版本的VFT。此外，在FES组中，在任一VFT期间均未观察到DUP与脑皮质活动之间的关联。总之，我们没有发现DUP和额颞叶皮质活动之间的关联。这可能是因为神经发育障碍导致神经认知缺陷早在精神病症状发作之前。
A longer duration of untreated psychosis (DUP) has been associated with poor clinical outcomes in patients with schizophrenia (SZ); however, it remains unclear whether this is due to neurotoxic effects of psychosis. The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in patients with first-episode SZ (FES). A total of 28 FES patients and 29 healthy controls (HC) underwent NIRS during VFTs. Group comparisons of cortical activity were made using two-tailed t-tests and the false discovery rate method. We then examined the associations between DUP and hemodynamic changes in each channel to identify any effects of DUP on brain cortical activity. During the letter VFT, the HC group exhibited significantly greater cortical activations over bilateral frontotemporal regions compared to FES patients. However, this distinction was not observed while performing a category version of the VFT. In addition, no associations between DUP and brain cortical activity were observed in the FES group during either VFT. In conclusion, we did not find an association between DUP and frontotemporal cortical activities. This might be because neurodevelopmental disturbances result in neurocognitive deficits long before psychotic symptoms onset.