Developmental lead exposure: behavioral alterations in the short and long term
Developmental lead exposure: behavioral alterations in the short and long term
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DOI：
10.1016/s0892-0362(01)00159-3
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发表时间：
2001-09-01
影响因子：
2.9
通讯作者：
Vassilieff, VS
中科院分区：
文献类型：
--
作者：
Moreira, EG;Vassilieff, I;Vassilieff, VS
Wistar 母鼠在怀孕和哺乳期的饮用水中暴露于 500 ppm 的铅（以醋酸 Ph 形式）或 660 ppm 的醋酸钠。对 23 天（断奶）或 70 天（成年）的雄性幼崽进行行为评估和 Pb 测定。评估的行为包括：运动活动（旷场测试）、运动协调性（旋转测试）、探索行为（洞板测试）、焦虑（高架迷宫和社交互动测试）以及学习和记忆（穿梭箱）。测量了母鼠和幼鼠血液和大脑区域（海马和纹状体）的 pH 水平。本报告的结果表明，在怀孕和哺乳期间接触Ph会导致断奶仔犬过度活跃、探索行为减少以及学习和记忆受损。这些变化是在长期暴露于低水平铅（21 +/- 3 微克/分升）的儿童可能达到的血液 pH 值范围内观察到的。对于成年人，结果表明，所采用的暴露方案会在这些动物的血液 pH 水平无法检测到的情况下引起焦虑。 (C) 2001 Elsevier Science Inc. 保留所有权利。
Wistar dams were exposed to 500 ppm of Pb, as Ph acetate, or 660 ppm Na acetate in drinking water during pregnancy and lactation. Male pups at 23 (weaned) or 70 days (adult) of age were submitted to behavioral evaluation and Pb determination. The behaviors evaluated were: locomotor activity (open-field test), motor coordination (rotarod test), exploratory behavior (holeboard test), anxiety (elevated plus maze and social interaction tests), and learning and memory (shuttle box). Ph levels were measured in the blood and cerebral regions (hippocampus and striatum) of dams and pups. The results of the present report demonstrated that exposure to Ph during pregnancy and lactation induces in weaned pups hyperactivity, decreased exploratory behavior, and impairment of learning and memory. These alterations were observed at blood Ph levels in the range that may be attained in children chronically exposed to low levels of Pb (21 +/- 3 mug/dl). Regarding adults, the results demonstrated that the regimen of exposure adopted induces anxiety in these animals at nondetectable blood Ph levels. (C) 2001 Elsevier Science Inc. All rights reserved.