Methyl protodioscin induces G2/M cell cycle arrest and apoptosis. in HepG2 liver cancer cells
Methyl protodioscin induces G2/M cell cycle arrest and apoptosis. in HepG2 liver cancer cells
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DOI：
10.1016/j.canlet.2005.10.050
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发表时间：
2006-09-08
期刊：
影响因子：
9.7
通讯作者：
Yao, Xinsheng
中科院分区：
文献类型：
--
作者：
Wang, Guanghui;Chen, Haifeng;Yao, Xinsheng
甲基原薯蓣皂苷（Methyl protodiooscin, NSC-698790）是中药薯蓣科（Dioscorea collettii vari . hypoglauca）中的主要活性成分之一。本研究探讨了原薯蓣皂苷甲酯对HepG2细胞的抗增殖作用及其诱导细胞毒性的机制。甲基原薯蓣皂苷处理可导致HepG2细胞的G2/M阻滞和凋亡。这些作用归因于Cyclin 131的下调以及导致Bax上调和BCL2下调的信号通路，表明甲基原diooscin可能是一种新的抗有丝分裂剂。2006爱思唯尔爱尔兰有限公司版权所有。
Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae). In this study, we investigated the anti-proliferative effect of methyl protodioscin on the HepG2 cells and the mechanism of the induced cytotoxicity. Treatment of methyl protodioscin resulted in G2/M arrest and apoptosis in HepG2 cells. These effects were attributed to down-regulation of Cyclin 131 and the signaling pathways leading to up-regulation of Bax and down-regulation of BCL2, suggesting that methyl protodioscin may be a novel anti-mitotic agent. (c) 2006 Elsevier Ireland Ltd. All rights reserved.