Incremental redistribution of protein kinase C underlies the acquisition curve during in vitro associative conditioning in Hermissenda.
Incremental redistribution of protein kinase C underlies the acquisition curve during in vitro associative conditioning in Hermissenda.
复制标题
蛋白激酶 C 的增量重新分布是 Hermissenda 体外联想调节过程中采集曲线的基础。
DOI：
10.1037//0735-7044.111.4.739
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发表时间：
1997
影响因子：
1.9
通讯作者：
Matzel,LD
中科院分区：
文献类型：
--
作者：
Muzzio,IA;Talk,AC;Matzel,LD
Hermissenda中B光感受器的兴奋性（即输入电阻、诱发尖峰频率）的递增伴随着光和前庭毛细胞突触前刺激的连续配对（模拟完整动物中的光旋转配对）。蛋白激酶C（PKC）在Hermissenda的光感受器的分析表明，训练诱导的增量减少PKC在胞质隔室，增加在膜隔室的趋势，和一个小的减少总酶活性（可能是由于下调或转换PKC的钙非依赖性状态）。在暴露于未配对光和旋转的Hermissenda中或在选择性PKC抑制剂NPC-15437（对突触相互作用或光诱导的发生器电位没有影响）存在下训练的Hermissenda中均未观察到生物物理或生物化学效应。这些结果表明，细胞内的蛋白激酶的重新分布有助于关键的新的学习动力学。（PsycInfo数据库记录（c）2024阿帕，保留所有权利）
An incremental increase in the excitability (ie, input resistance, evoked spike frequency) of B photoreceptors in Hermissenda accompanied successive pairings of light and presynaptic stimulation of vestibular hair cells (simulating light-rotation pairings in an intact animal). Analysis of protein kinase C (PKC) in the Hermissenda's photoreceptors indicated a training-induced incremental reduction of PKC in cytosolic compartments, a tendency toward an increase in membrane compartments, and a small decrease in total enzyme activity (possibly owing to a downregulation or conversion of PKC to a calcium-independent state). Neither the biophysical or biochemical effects were observed in Hermissenda exposed to unpaired light and rotation or in those trained in the presence of the selective PKC inhibitor NPC-15437 (which had no effect on synaptic interactions or light-induced generator potentials). These results suggest that the intracellular redistribution of a protein kinase contributes critically to the kinetics of new learning.(PsycInfo Database Record (c) 2024 APA, all rights reserved)