Transcutaneous Vagus Nerve Stimulation: A Promising Method for Treatment of Autism Spectrum Disorders.
Transcutaneous Vagus Nerve Stimulation: A Promising Method for Treatment of Autism Spectrum Disorders.
复制标题
经皮神经刺激：一种有前途的自闭症谱系障碍的方法。
DOI：
10.3389/fnins.2016.00609
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发表时间：
2016
影响因子：
4.3
通讯作者：
Kong J
中科院分区：
文献类型：
--
作者：
Jin Y;Kong J
迷走神经耳分支上的经皮迷走神经刺激（tVNS）由于其对神经精神疾病的治疗潜力而受到关注。虽然tVNS的机制尚未完全了解，但研究已经证明迷走传入神经刺激在调节与社会交往相关的情绪和内脏状态中的潜在作用。此外，越来越多的证据表明，tVNS可以激活与自闭症谱系障碍（ASD）相关的大脑区域，触发神经免疫调节，并对ASD的共病疾病（如癫痫和抑郁症）产生治疗效果。因此，我们假设，tVNS可能是一个有前途的治疗ASD，不仅为共病癫痫和抑郁症，但也为ASD的核心症状。本文的目的是总结应用tVNS治疗ASD的结果和原理，并提出tVNS治疗ASD的潜在参数。
Transcutaneous Vagus Nerve Stimulation (tVNS) on the auricular branch of the vagus nerve has been receiving attention due to its therapeutic potential for neuropsychiatric disorders. Although the mechanism of tVNS is not yet completely understood, studies have demonstrated the potential role of vagal afferent nerve stimulation in the regulation of mood and visceral state associated with social communication. In addition, a growing body of evidence shows that tVNS can activate the brain regions associated with Autism Spectrum Disorder (ASD), trigger neuroimmune modulation and produce treatment effects for comorbid disorders of ASD such as epilepsy and depression. We thus hypothesize that tVNS may be a promising treatment for ASD, not only for comorbid epilepsy and depression, but also for the core symptoms of ASD. The goal of this manuscript is to summarize the findings and rationales for applying tVNS to treat ASD and propose potential parameters for tVNS treatment of ASD.