Acute graft-versus-host disease of the gut.
Acute graft-versus-host disease of the gut.
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DOI：
10.2169/internalmedicine.34.751
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发表时间：
1995-08
影响因子：
1.2
通讯作者：
T. Izumi;Youichi Amemiya;Noriaki Iwao;Toshiyuki Suzuki;Kazuo Muroi;Minoru Yoshida;K. Hatake;Yasusada Miura;Noribumi Hitomi;Makio Hatakeyama;Kenji Nakazawa;Ken Saito
中科院分区：
文献类型：
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作者：
T. Izumi;Youichi Amemiya;Noriaki Iwao;Toshiyuki Suzuki;Kazuo Muroi;Minoru Yoshida;K. Hatake;Yasusada Miura;Noribumi Hitomi;Makio Hatakeyama;Kenji Nakazawa;Ken Saito
一名 28 岁男性患有首次早期复发的急性早幼粒细胞白血病，在首次早期复发时接受了 HLA 匹配的同种异体骨髓移植 (BMT)。以常规剂量施用环孢素 A 和甲氨蝶呤作为移植物抗宿主病 (GVHD) 的预防。 BMT 后第 87 天，他出现严重血性腹泻。下消化道检查发现粘膜弥漫性炎症变化。在没有皮肤和肝脏受累等其他表现的情况下，诊断为迟发性急性肠道 GVHD。需要进一步调查来阐明非典型肠道 GVHD 的发生率和发病机制。
A 28-year-old man with acute promyelocytic leukemia at first early relapse received HLA-matched allogenic bone marrow transplantation (BMT) at first early relapse. Cyclosporin A and methotrexate were administered at conventional doses as a prophylaxis for graft-versus-host disease (GVHD). He presented with severe bloody diarrhea on day 87 after BMT. Examination of the lower gastrointestinal tract revealed diffuse mucosal change of inflammation. A diagnosis of late onset of acute gut GVHD was made, in the absence of other manifestations such as skin and liver involvement. A further survey is needed to clarify the incidence and the pathogenesis of atypical gut GVHD.