Metabolic syndrome and endothelin-1 mediated vasoconstrictor tone in overweight/obese adults.
Metabolic syndrome and endothelin-1 mediated vasoconstrictor tone in overweight/obese adults.
复制标题
超重/肥胖成人的代谢综合征和内皮素-1 介导的血管收缩张力。
DOI：
10.1016/j.metabol.2014.04.007
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
DeSouza,ChristopherA
中科院分区：
文献类型：
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作者：
Rocha,NataliaG;Templeton,DanielleL;Greiner,JaredJ;Stauffer,BrianL;DeSouza,ChristopherA
目的探讨超重和肥胖的代谢综合征(METS)患者是否存在较高的血管收缩张力。材料/方法40例超重/肥胖中老年患者(年龄43~71岁，BMI：25.1~36.9 kg/m2)，其中20例无代谢综合征患者(男13例，女13例)和20例(男13例，女13例)。METS是根据NCEP ATPIII指南建立的。分别测定选择性ETA受体阻滞剂(BQ-123；100nmol/min，60min)和非选择性ETA/B受体阻滞剂(BQ-123+BQ-788[50nmol/min，60min])对前臂血流量(FBF)的影响。但超重/肥胖组前臂血流量增加显著高于未服用蛋氨酸组(P=0.03；~0.45%)。相反，非选择性ETA/B受体阻断剂对FBF的反应没有显著的组间差异。超重/肥胖组和有MetS组对非选择性ETA/B受体阻滞剂的最大血管扩张反应比基础血流高约50%。结论Mets与超重/肥胖组ET-1收缩张力升高有关。Mets增强ET-1的血管收缩活性是通过ETA受体亚型介导的。
ObjectiveTo determine whether endothelin (ET)-1 vasoconstrictor tone is greater in overweight and obese adults with the metabolic syndrome (MetS).Materials/MethodsForty overweight/obese middle-aged and older adults (age: 43–71 years; BMI: 25.1–36.9 kg/m2) were studied: 20 without MetS (13 M/7 F) and 20 with MetS (13 M/7 F). MetS was established according to NCEP ATP III guidelines. Forearm blood flow (FBF; plethysmography) responses to intra-arterial infusion of selective ETAreceptor blockade (BQ-123; 100 nmol/min; for 60 min) and non-selective ETA/Breceptor blockade (BQ-123 + BQ-788 [50 nmol/min for 60 min]) were determined.ResultsIn response to the selective ETAantagonism, there was a significant increase in forearm blood flow from baseline in both groups. However, the increase in forearm blood flow was significantly higher (P = 0.03; ~ 45%) in the overweight/obese group with MetS than the group without MetS. In contrast, there were no significant group differences in FBF responses to non-selective ETA/Breceptor blockade. Peak vasodilator responses to nonselective ETA/Bblockade were ~ 50% higher than baseline blood flow in the overweight/obese groups without and with MetS.ConclusionMetS is associated with higher ET-1 vasoconstrictor tone in overweight/obese adults. The enhanced ET-1 vasoconstrictor activity with MetS is mediated by the ETAreceptor subtype.