Osteoporosis and sarcopenia are associated with each other and reduced IGF1 levels are a risk for both diseases in the very old elderly
Osteoporosis and sarcopenia are associated with each other and reduced IGF1 levels are a risk for both diseases in the very old elderly
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DOI：
10.1016/j.bone.2022.116570
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发表时间：
2022-10-13
期刊：
影响因子：
4.1
通讯作者：
Miyamoto, Takeshi
中科院分区：
文献类型：
--
作者：
Hata, Ryosuke;Miyamoto, Kana;Miyamoto, Takeshi
管理老年人的肌肉骨骼疾病是强制性的，以防止他们卧床不起或需要长期护理。然而，在85岁以上的健康人群中，骨质疏松症和骨骼肌减少症等肌肉骨骼疾病的患病率尚不完全清楚。在这里，我们招募了1026名年龄在85至89岁之间的健康受试者，并评估了他们是否存在骨质疏松症、肌肉减少症和脆性骨折，以及这些疾病之间的关系。我们还评估了生物标志物，如血清胰岛素样生长因子1 （IGF1）水平和维生素D状态。骨质疏松症、肌肉减少症和脆性骨折的患病率分别为22.4%、10.2%和15.0%。血清IGF1和25(OH)D与骨质疏松症或肌肉减少症呈显著负相关。即使在性别和BMI调整后，骨质疏松症和肌肉减少症或脆性骨折仍显着相关，并显示为彼此的危险因素，而肌肉减少症和脆性骨折则不相关。我们的数据可能为老年人提供一个健康平台，并提出预防这一人群肌肉骨骼疾病的策略。
It is mandatory to manage musculoskeletal disorders in the elderly to prevent their becoming bed-ridden or requiring long-term care. However, the prevalence of musculoskeletal disorders such as osteoporosis and sar-copenia in otherwise healthy people over 85 years old is not completely known. Here we enrolled 1026 healthy subjects between 85 and 89 years old and evaluated them for the presence of osteoporosis, sarcopenia and fragility fracture(s), and how those conditions were related. We also evaluated biomarkers such as serum levels of insulin-like growth factor 1 (IGF1) and vitamin D status. The prevalence of osteoporosis, sarcopenia or fragility fracture(s) in these subjects was 22.4, 10.2 or 15.0 %, respectively. Serum IGF1 and 25(OH)D were significantly and negatively correlated with osteoporosis or sarcopenia. Osteoporosis and either sarcopenia or fragility frac-ture(s) were significantly related and shown to be risk factors for each other, even after adjustment for gender and BMI, while sarcopenia and fragility fracture(s) were not associated. Our data may provide a health platform for the very elderly and suggest strategies to prevent musculoskeletal disorders in this population.