Ocular findings in patients with psoriasis
Ocular findings in patients with psoriasis
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DOI：
10.1111/j.1365-4632.2011.05424.x
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发表时间：
2013-05-01
影响因子：
3.6
通讯作者：
Ozmen, Sedat
中科院分区：
文献类型：
--
作者：
Kilic, Berna;Dogan, Umit;Ozmen, Sedat
银屑病是一种影响皮肤、指甲和关节的慢性炎症性疾病。虽然文献中没有很多报道，但大约10%的患者会出现眼部症状，其中大多数是银屑病关节炎患者。在本研究中，我们旨在评估牛皮癣患者的眼部受累情况。方法对100例银屑病患者和100名健康人群进行研究。从所有研究对象和对照对象中获取病史，进行皮肤、全身和眼科检查，并测量Schirmer值和BUT值。常数变量比较采用t检验，分类变量比较采用卡方检验。使用logistic回归分析评估眼部表现与性别、年龄、银屑病病程、PASI评分、眼睑银屑病斑块存在、指甲受累和银屑病关节炎之间的关系。分别对右眼和左眼进行统计分析。结果患者组双眼病变数明显高于对照组，差异有统计学意义。患者组的Schirmer和BUT值均低于对照组，差异有统计学意义。结论虽然本研究结果支持对银屑病患者进行常规眼科检查对早期诊断和治疗的必要性，但我们认为银屑病患者眼部受累的发病机制仍需进一步研究。
Background Psoriasis is a chronic inflammatory disease affecting skin, nails, and joints. Although there are not many reports in the literature, ocular findings occur in approximately 10% of patients, in mostly those who have psoriatic arthritis. In this study, we aimed to evaluate eye involvement in psoriasis patients. Methods This study was performed on a total of 100 psoriasis patients and a group of 100 healthy individuals. History was taken from all study and control subjects, and dermatological, systemic, and ophthalmological examinations were performed and Schirmer and BUT values were measured. Constant variables were compared using the t-test, and categorical variables were compared using chi-square test. Relationship between ocular findings and sex, age, duration of psoriasis, PASI score, presence of psoriatic plaques on the eyelid, nail involvement, and psoriatic arthritis was evaluated using logistic regression analysis. Statistical analyses were performed individually for both right and left eyes. Results The number of ocular findings in both eyes in the patient group was found to be statistically higher than that in the control group. Schirmer and BUT values were statistically lower in the patient group than those in the control group. Conclusions Although results of our study support the necessity of routine ophthalmological examination of psoriasis patients for early diagnosis and treatment, we believe that further studies are required on the etiopathogenesis of ocular involvement in psoriasis patients.