COHERENT NETWORK OSCILLATIONS BY OLFACTORY INTERNEURONS - MODULATION BY ENDOGENOUS AMINES
COHERENT NETWORK OSCILLATIONS BY OLFACTORY INTERNEURONS - MODULATION BY ENDOGENOUS AMINES
复制标题
DOI：
10.1152/jn.1993.69.6.1930
复制
发表时间：
1993-06-01
影响因子：
2.5
通讯作者：
TANK, DW
中科院分区：
文献类型：
--
作者：
GELPERIN, A;RHINES, LD;TANK, DW
1.陆生软体动物Limax maximus的大脑前叶（PC）包含一个高度互连的局部嗅觉中间神经元网络，该网络接收来自两对鼻子的直接轴突投射。这个嗅觉处理网络在其局部场电位（LFP）中产生0.7 Hz的振荡，该振荡在整个网络中是一致的。振荡的LFP由施加到上级鼻子的神经上皮的天然气味剂调制。已知存在于PC叶中的两种胺，多巴胺和血清素，增加PC叶振荡的频率并改变其波形。谷氨酸，另一种已知存在于叶中的假定神经递质，通过quisqualate型受体抑制PC叶振荡，并且似乎被PC叶中的两类神经元中的一种用于产生基本LFP振荡。多巴胺和5-羟色胺对Limax PC叶中第二信使的已知激活及其对振荡节律的影响表明，这些胺增强了嗅觉网络中介导突触可塑性的机制，类似于脊椎动物嗅觉系统中胺的假设作用。使用一个分布式网络的interneurons显示相干振荡可能涉及到高度发达的气味识别和气味学习能力的Limax。
1. The procerebral (PC) lobe of the terrestrial mollusk Limax maximus contains a highly interconnected network of local olfactory interneurons that receives direct axonal projections from the two pairs of noses. This olfactory processing network generates a 0.7-Hz oscillation in its local field potential (LFP) that is coherent throughout the network. The oscillating LFP is modulated by natural odorants applied to the neuroepithelium of the superior nose.2. Two amines known to be present in the PC lobe, dopamine and serotonin, increase the frequency of the PC lobe oscillation and alter its waveform.3. Glutamate, another putative neurotransmitter known to be present in the lobe, suppresses the PC lobe oscillation by a quisqualate-type receptor and appears to be used by one of the two classes of neurons in the PC lobe to generate the basic LFP oscillation.4. The known activation of second messengers in Limax PC lobe by dopamine and serotonin together with their effects on the oscillatory rhythm suggest the hypothesis that these amines augment mechanisms mediating synaptic plasticity in the olfactory network, similar to hypothesized effects of amines in vertebrate olfactory systems.5. The use of a distributed network of interneurons showing coherent oscillations may relate to the highly developed odor recognition and odor learning ability of Limax.