Counterfactual cognitive deficit in persons with Parkinson's disease
Counterfactual cognitive deficit in persons with Parkinson's disease
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DOI：
10.1136/jnnp.74.8.1065
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发表时间：
2003-08-01
影响因子：
11
通讯作者：
Lynch, A
中科院分区：
文献类型：
--
作者：
McNamara, P;Durso, R;Lynch, A
背景：反事实是对过去事件的替代的心理表征。最近的研究表明，他们是重要的其他认知过程，如规划，因果推理，解决问题，决策-所有的过程独立地连接到frontallebes.Objective：要测试的假设，即反事实思维受损的一些帕金森氏病患者，并在这些患者的额叶功能障碍。方法.对24名帕金森病患者和15名年龄匹配的健康对照者进行了反事实处理和额叶功能的测量。结果帕金森病患者自发产生的反事实显着少于对照组，尽管没有显示出任何差异，从控制的语义流畅性测试，他们也表现在机会水平上的反事实推理测试，而年龄匹配的对照组在此测试上的机会水平。两个反事实的生成和推理测试的性能显着相关的两个测试传统上与额叶功能（Stroop色字干扰和伦敦塔规划任务）和一个测试的务实的社会交际技能。结论：反事实思维受损帕金森氏病。这种损害可能与额叶功能障碍有关。
Background: Counterfactuals are mental representations of alternatives to past events. Recent research has shown them to be important for other cognitive processes, such as planning, causal reasoning, problem solving, and decision making - all processes independently linked to the frontal lobes.Objective: To test the hypothesis that counterfactual thinking is impaired in some patients with Parkinson's disease and is linked to frontal dysfunction in these patients. Methods. Measures of counterfactual processing and frontal lobe functioning were administered to 24 persons with Parkinson's disease and 15 age matched healthy controls. Results. Patients with Parkinson's disease spontaneously generated significantly fewer counterfactuals than controls despite showing no differences from controls on a semantic fluency test; they also performed at chance levels on a counterfactual inference test, while age matched controls performed above chance levels on this test. Performance on both the counterfactual generation and inference tests correlated significantly with performance on two tests traditionally linked to frontal lobe functioning (Stroop colour - word interference and Tower of London planning tasks) and one test of pragmatic social communication skills.Conclusions: Counterfactual thinking is impaired in Parkinson's disease. This impairment may be related to frontal lobe dysfunction.