Quantitative structure-activity relationships for toxicity and genotoxicity of halogenated aliphatic compounds:: Wing spot test of Drosophila melanogaster
Quantitative structure-activity relationships for toxicity and genotoxicity of halogenated aliphatic compounds:: Wing spot test of Drosophila melanogaster
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DOI：
10.1016/j.chemosphere.2006.09.020
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发表时间：
2007-02-01
期刊：
影响因子：
8.8
通讯作者：
Damborsky, Jiri
中科院分区：
文献类型：
--
作者：
Chroust, Karel;Pavlova, Martina;Damborsky, Jiri
在使用黑腹果蝇的体细胞突变和重组试验中，评价了卤代脂肪族化合物的毒性和遗传毒性效应。测试的化学品包括氯化、溴化和碘化;单取代、二取代和三取代;饱和和不饱和烷烃：1，2-二溴乙烷、1-溴-2-氯乙烷、1-碘丙烷、2，3-二氯丙烯、3-溴-1-丙烯、表溴醇、2-碘丁烷、3-氯-2-甲基丙烯、1，2，3-三氯丙烷、1，2-二氯乙烷、1，2-二氯丁烷、1，1-氯-2-甲基丙烷，1，3-二氯丙烷、1，2-二氯丙烷、2-氯乙基甲基醚、1-溴-2-甲基丙烷和1-氯戊烷。N-甲基-N-亚硝基脲作为阳性对照，蒸馏水作为阴性对照。通过使用统计实验设计选择毒理学试验的化学品组。不饱和脂肪族烃的毒性一般比饱和类似物大。在翅斑试验中，14种化合物观察到遗传毒性效应，而在50%致死浓度下，3种化合物在翅斑试验中未显示任何遗传毒性。在遗传毒性试验中，1-溴-2-氯乙烷、1，2-二氯乙烷、1，2-二溴乙烷和1-碘丙烷的翅斑数最高。用量子力学计算的亲核超离域性是预测卤代脂肪族化合物毒性和遗传毒性效应的一个很好的参数。(c)2006年由Elsevier Ltd.出版
Halogenated aliphatic compounds were evaluated for toxic and genotoxic effects in the somatic mutation and recombination test employing Drosophila melanogaster. The tested chemicals included chlorinated, brominated and iodinated; mono-, di- and tri-substituted; saturated and unsaturated alkanes: 1,2-dibromoethane, 1-bromo-2-chloroethane, 1-iodopropane, 2,3-dichloropropene, 3-bromo-1-propene, epibromohydrin, 2-iodobutane, 3-chloro-2-methylpropene, 1,2,3-trichloropropane, 1,2-dichloroethane, 1,2-dichlorobutane, ,1-chloro-2-methylpropane, 1,3-dichloropropane, 1,2-dichloropropane, 2-chloroethymethylether, 1-bromo-2-methylpropane and 1-chloropentane. N-methyl-N-nitrosourea served as the positive and distilled water as the negative control. The set of chemicals for the toxicological testing was selected by the use of statistical experiment design. Group of unsaturated aliphatic hydrocarbons were generally more toxic than saturated analogues. The genotoxic effect was observed with 14 compounds in the wing spot test, while 3 substances did not show any genotoxicity by using the wing spot test at 50% lethal concentration. The highest number of wing spots was observed in genotoxicity assay with 1-bromo-2-chloroethane, 1,2-dichloroethane, 1,2-dibromoethane and 1-iodopropane. Nucleophilic superdelocalizability calculated by quantum mechanics appears to be a good parameter for prediction of both toxicity and genotoxicity effects of halogenated aliphatic compounds. (c) 2006 Published by Elsevier Ltd.