Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease
Intake of fiber and nuts during adolescence and incidence of proliferative benign breast disease
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DOI：
10.1007/s10552-010-9532-7
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发表时间：
2010-07-01
影响因子：
2.3
通讯作者：
Colditz, Graham A.
中科院分区：
文献类型：
--
作者：
Su, Xuefen;Tamimi, Rulla M.;Colditz, Graham A.
在护士健康研究II中，我们研究了青少年纤维摄入量与增殖性BBD（乳腺癌风险增加的标志物）之间的关系。在1998年完成高中饮食问卷调查的29，480名女性中，在1991年至2001年期间，通过集中病理学审查确定并确认了682例增殖性BBD病例。多变量校正的考克斯比例风险回归用于估计风险比（HR）和95%置信区间（CI）。青少年纤维摄入量最高五分位数的妇女比最低五分位数的妇女增殖性BBD的风险低25%（多变量HR（95%CI）：0.75（0.59，0.96），p趋势= 0.01）。高中生摄入坚果也与显著降低BBD风险有关。与每月食用1份坚果的女性相比，每周食用1份坚果的女性风险降低36%（多变量HR（95% CI）：0.64（0.48，0.85），p趋势< 0.01）。当分析仅限于高中饮食问卷返回后诊断的前瞻性病例（n = 142）时，结果基本相同。这些发现支持了这样的假设，即青春期纤维和坚果的饮食摄入量会影响随后患乳腺疾病的风险，并可能建议一种可行的方法预防乳腺癌。
We examined the association between adolescent fiber intake and proliferative BBD, a marker of increased breast cancer risk, in the Nurses' Health Study II.Among 29,480 women who completed a high school diet questionnaire in 1998, 682 proliferative BBD cases were identified and confirmed by centralized pathology review between 1991 and 2001. Multivariate-adjusted Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).Women in the highest quintile of adolescent fiber intake had a 25% lower risk of proliferative BBD (multivariate HR (95% CI): 0.75 (0.59, 0.96), p-trend = 0.01) than women in the lowest quintile. High school intake of nuts was also related to significantly reduced BBD risk. Women consuming a parts per thousand yen2 servings of nuts/week had a 36% lower risk (multivariate HR (95% CI): 0.64 (0.48, 0.85), p-trend < 0.01) than women consuming < 1 serving/month. Results were essentially the same when the analysis was restricted to prospective cases (n = 142) diagnosed after return of the high school diet questionnaire.These findings support the hypothesis that dietary intake of fiber and nuts during adolescence influences subsequent risk of breast disease and may suggest a viable means for breast cancer prevention.