[Analytical data of designated substances (Shitei-Yakubutsu) controlled by the Pharmaceutical Affairs Law in Japan, part I: GC-MS and LC-MS].
[Analytical data of designated substances (Shitei-Yakubutsu) controlled by the Pharmaceutical Affairs Law in Japan, part I: GC-MS and LC-MS].
复制标题
[日本药事法管制指定物质（Shitei-Yakubutsu）的分析数据，第 I 部分：GC-MS 和 LC-MS]。
DOI：
10.1248/yakushi.128.971
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Yukihiro Goda
中科院分区：
文献类型：
--
作者：
Ruri Kikura;Maiko Kawamura;Nahoko Uchiyama;Jun Ogata;H. Kamakura;Kazuhiro Saisho;Yukihiro Goda
在过去10年中，许多麻醉品类似物作为容易获得的精神药物在日本广泛销售，这已成为一个严重问题。它们通过互联网或音像店作为视频清洁剂、熏香和试剂出售。它们不受《麻醉品和精神药物管制法》管制，因为它们的药理作用尚未得到科学证明。作为防止滥用这些物质的对策，厚生劳动省于2006年修订了《药事法》，（11种色胺，11种苯乙胺，6种亚硝酸烷基酯，截至2007年4月，1种植物（鼠尾草）和2种哌嗪和鼠尾草素A现在作为“指定物质（Shitei-Yakubutsu）”受到管制。2008年1月，还将另外5种化合物（4种苯乙胺和1种哌嗪）列入这一类别。在这项研究中，我们开发了这些指定物质的同时分析方法，使用气相色谱-质谱（GC-MS）和液相色谱-质谱（LC-MS），并提供保留时间，紫外光谱，电子电离（EI），GC-MS和电喷雾电离（ESI）LC-MS数据。
In the last 10 years, many analogs of narcotic substances have been widely distributed in Japan as easily available psychotropic substances and this has become a serious problem. They have been sold as video cleaners, incense and reagents via the Internet or in video shops. They are not controlled under the Narcotics and Psychotropics Control Law because their pharmacological effects have not yet been proved scientifically. As a countermeasure to prevent the abuse of these substances, the Ministry of Health, Labor and Welfare amended the Pharmaceutical Affairs Law in 2006 so that 31 non-controlled psychotropic substances (11 tryptamines, 11 phenethylamines, 6 alkyl nitrites, 2 piperazines and salvinorin A) and 1 plant (Salvia divinorum) are now controlled as "Designated Substances (Shitei-Yakubutsu)" as of April 2007. Five other compounds (4 phenethylamines and 1 piperazine) were also added to this category in January 2008. In this study, we developed simultaneous analytical methods for these designated substances using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) and present retention times, UV spectra, electron ionization (EI), GC-MS, and electrospray ionization (ESI) LC-MS data.