The epidemiology of infant cancers.
The epidemiology of infant cancers.
复制标题
婴儿癌症的流行病学。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
V. Blair
中科院分区：
文献类型：
--
作者：
J. Birch;V. Blair
婴儿癌症在所有恶性肿瘤中所占比例不到0.05%，但构成了一个特别有趣的研究群体。在1-14岁的儿童中，实体瘤与白血病的比例为2：1，而在1岁以下的婴儿中，实体瘤与白血病的比例为5：1。神经母细胞瘤是婴儿中最常见的恶性肿瘤，1岁以下儿童的发病率是1-14岁儿童的四倍。其他胚胎肿瘤，如肾母细胞瘤、肝母细胞瘤和视网膜母细胞瘤在婴儿中的发病率也较高。在两个年龄组中，男女发病率在若干情况下有所不同，如白血病和肝脏肿瘤。1-14岁儿童的男女发病率比1-14岁儿童高，但在婴儿中不到1。这些观察表明，许多婴儿肿瘤可能在病因上是不同的。它们的早期发病和以胚胎为主的性质表明，出生前的起源和遗传因素可能是重要的。
Cancers in infants represent less than 0.05% of all malignant neoplasms, but form a particularly interesting group for study. The ratio of solid tumours to leukaemias is 2:1 in children aged 1-14 but 5:1 in infants less than 1 year. The rate for neuroblastoma which is the most common malignancy in infants is four times higher in children aged under 1 year than in 1-14 year olds. Other embryonal tumours, e.g. Wilms', heptablastoma and retinoblastoma also show higher rates in infants. The ratios of incidence in males to females differed in a number of instances in the two age groups, e.g. in leukaemias and liver tumours the male to female ratio is greater than one in 1-14 year old children but less than one in infants. These observations suggest that many infant tumours may be aetiologically distinct. Their early onset and predominantly embryonal nature suggest a pre-natal origin and genetic factors may be important.
影响因子：
56.9
作者：
MALKIN, D;LI, FP;FRIEND, SH
通讯作者：
FRIEND, SH