Reactions of cells to topography
Reactions of cells to topography
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DOI：
10.1163/156856298x00415
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发表时间：
1998-01-01
影响因子：
3.6
通讯作者：
Wilkinson, CD
中科院分区：
文献类型：
--
作者：
Curtis, ASG;Wilkinson, CD
虽然从细胞培养的早期就已经知道了接触引导，但很少对细胞对形貌的反应进行定量检查，下面将突出说明这种主观方法。然而，如果我们要了解细胞如何反应，如果我们要能够为特定细胞设计理想的基质，我们需要这些信息，精确度和定量是细胞检查方法和拓扑结构定义所必需的。最近已经清楚的是，这些反应发生在纳米尺度上，并且对于细胞工程和组织修复具有重要意义。地形似乎为细胞提供了一组非常强大的信号。
Though contact guidance has been known since the very early days of cell culture very little quantitative examination of the reaction of cells to topography has been made, Exceptions to this subjective approach are given prominence below. Yet if we are to understand how cells react and if we are to be able to design ideal substrata for particular cells we need this information, Precision and quantitation are required both of the methods of examination of the cells but also in the definition of that topography. Recently it has become clear that the these reactions occur at the nanometric scale and have importance for use in cellular engineering and tissue repair. Topography appears to provide a set of very powerful signals for cells.