Catalytic dehalogenation of aryl chlorides mediated by ruthenium(II) phosphine complexes
Catalytic dehalogenation of aryl chlorides mediated by ruthenium(II) phosphine complexes
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DOI：
10.1021/om980682n
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发表时间：
1999-03-29
期刊：
影响因子：
2.8
通讯作者：
Grubbs, RH
中科院分区：
文献类型：
--
作者：
Cucullu, ME;Nolan, SP;Grubbs, RH
The catalytic dechlorination of aryl chlorides performed by RuHCl(H-2)(2)(PCy3)(2) and RuH2(H-2)(2)(PCy3)(2) in alcohols is rapid and complete within 1 h. The mechanism involves a transfer hydrogenation step with participation of the alcohol. The system exhibits significant functional group tolerance. The catalyst can be generated in situ from [RuCl2(COD)](x) (COD = cyclooctadiene) and 2 equiv of phosphine (PCy3 or (PPr3)-Pr-i). Catalytic conversions are similar to those observed when an isolated precatalyst is used. Mechanistic considerations and the scope of the process are discussed.
