EPIDEMIOLOGY OF PRIMARY SCLEROSING CHOLANGITIS IN SPAIN
EPIDEMIOLOGY OF PRIMARY SCLEROSING CHOLANGITIS IN SPAIN
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DOI：
10.1016/s0168-8278(94)80240-8
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发表时间：
1994-11-01
影响因子：
25.7
通讯作者：
DELAMORENA, E
中科院分区：
文献类型：
--
作者：
ESCORSELL, A;PARES, A;DELAMORENA, E
原发性硬化性胆管炎的发病率是根据其与溃疡性结肠炎的频繁相关性来估计的，但尚未进行直接的流行病学研究。在目前的研究中，我们报告了一项调查的临床和流行病学方面的原发性硬化性胆管炎在西班牙，一份调查问卷分发给医生在33家医院在西班牙各地，以确定的数量和临床，生化和免疫学特征的原发性硬化性胆管炎患者从1984年1月1日至1988年12月31日。来自西班牙12个地区的23个中心，覆盖1923万人口回答了问卷。在5年期间观察到43例患者（60.5%男性），平均年龄为42.3岁（范围12 - 75岁）。16%的病例在就诊时无症状。溃疡性结肠炎出现在44.2%的病例中，1例患者患有克罗恩病。从1985年到1988年，总的年发病率范围为0.16 - 0.68例/百万，年患病率从1984年的0.78例/百万增加到1988年的2.24例/百万。没有发现地域差异，但有一种趋势是在工业化地区发现更多的病例。总之，西班牙原发性硬化性胆管炎的年发病率和患病率在5年内持续上升。(C)肝病学杂志。
The incidence of primary sclerosing cholangitis has been estimated on the basis of its frequent association with ulcerative colitis, but direct epidemiologic studies have not yet been carried out. In the current study we report a survey of clinical and epidemiological aspects of primary sclerosing cholangitis in Spain, A questionnaire was circulated to physicians in 33 hospitals throughout Spain to ascertain the number and the clinical, biochemical and immunologic characteristics of patients with primary sclerosing cholangitis from January 1, 1984 to December 31, 1988. Twenty-three centers, from 12 Spanish regions, covering a population of 19.23 million answered the questionnaire. Forty-three patients (60.5% males) with a mean age of 42.3 years (range 12 to 75 years) were seen during the 5-year period. At presentation, 16% of the cases were asymptomatic. Ulcerative colitis was present in 44.2% of cases, and one patient had Crohn's disease. The overall annual incidence ranged from 0.16 to 0.68 cases/million from 1985 to 1988, and the annual prevalence increased from 0.78 cases/million in 1984 to 2.24 cases/million in 1988. No geographical differences were found, but there was a trend to detect more cases in industrialized regions. In conclusion, there was a continuing rise in the annual incidence and prevalence of primary sclerosing cholangitis in Spain over a 5-year period. (C) Journal of Hepatology.