Clinical features of infants with subependymal germinolysis and choroid plexus cysts
Clinical features of infants with subependymal germinolysis and choroid plexus cysts
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DOI：
10.1111/j.1442-200x.2003.t01-1-01814.x
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发表时间：
2003-12-01
影响因子：
1.4
通讯作者：
Nakamura, H
中科院分区：
文献类型：
--
作者：
Herini, E;Tsuneishi, S;Nakamura, H
背景：脑室周围囊肿在新生儿中并不少见。方法：对13例(3例早产儿)脑室周围囊肿儿行常规颅脑超声检查，并进行回顾性随访研究。10例为单个或多个生殖细胞溶解囊肿，3例为脉络丛囊肿。所有婴儿均有各种潜在的并发症，包括先天性病毒感染(2例巨细胞病毒感染，1例风疹)，Sotos综合征4例，宫内发育迟缓5例，早产儿4例，先天性心脏病1例，脊髓膨出1例，其他微小畸形。除1例外，所有生殖细胞溶解病例均出现神经发育异常和/或延迟。相反，三例脉络丛囊肿尽管有潜在的并发症，但进展良好。结论：生殖细胞溶解囊肿似乎与全身疾病有关，应作为神经发育受损的高危征象来对待。
Background: Periventricular cysts arenot rare findings in neonates. However, they are sometimes associated withserious clinical complications, such as congenital viral infectionsand anomalies.Methods: We performed a retrospectivefollow-up study on newborns who had periventricular cysts on routinecranial ultrasound examination.Results: We followed 13 infants (threepreterm) with periventricular cysts. Ten had single or multiple germinolysiscysts and the remaining three had choroid plexus cysts. All infantshad various kinds of underlying complications, including congenitalviral infection (two with cytomegalovirus and one with rubella),Sotos syndrome (n = 4), intrauterinegrowth retardation (n = 5), large-for-dates(n = 4), congenital heart disease (n = 1),myelomeningocele (n = 1) and other minoranomalies. All cases of germinolysis except for one developed aneurodevelopmental abnormality and/or delay. In contrast,all three cases with choroid plexus cysts appeared to develop well,despite the underlying complications.Conclusions: Germinolysis cysts seem tobe associated with systemic diseases and should be treated as a high-risksign for impaired neurological development.